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Toxin-Induced Models of Neurological Disorders

  • Book
  • © 1994

Overview

Editors:
  1. Michael L. Woodruff

    1. East Tennesee State University, Johnson City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Arthur J. Nonneman

    1. Asbury College, Wilmore, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Animal Models and the Implications of Their Use

    • Arthur J. Nonneman, Michael L. Woodruff
    Pages 1-15

  3. Strategies for Developing Animal Models of Neurotoxicant-Induced Neurodegenerative Disorders

    • Paul R. Solomon, Maryellen Groccia-Ellison, Mark E. Stanton, William W. Pendlebury
    Pages 17-38

  4. Experimental Paradigms of Motor Neuron Degeneration

    • Michael J. Strong, Ralph M. Garruto
    Pages 39-88

  5. 6-Hydroxydopamine Lesions of Nigrostriatal Neurons as an Animal Model of Parkinson’s Disease

    • Paul J. Reading, Stephen B. Dunnett
    Pages 89-119

  6. MPTP-Treated Mice: A Useful Model for Parkinson’s Disease?

    • Erik Sundström, Bengt G. Henriksson, Abdul H. Mohammed, Frédéric Souverbie
    Pages 121-137

  7. Behavioral Effects of MPTP Administration in the Vervet Monkey

    • J. R. Taylor, J. D. Elsworth, R. H. Roth, J. R. Sladek Jr., D. E. Redmond Jr.
    Pages 139-174

  8. Intranigral Iron Infusion as a Model for Parkinson’s Disease

    • G. W. Arendash, G. J. Sengstock, C. W. Olanow, S. Barone Jr., A. J. Dunn
    Pages 175-212

  9. Excitotoxic Lesions of the Neostriatum as an Animal Model of Huntington’s Disease

    • Dwaine F. Emerich, David W. Cahill, Paul R. Sanberg
    Pages 213-257

  10. The Use of AF64A (Ethylcholine Aziridinium Ion) to Model Alzheimer’s Disease

    • Thomas J. Walsh, Karen D. Opello
    Pages 259-279

  11. Perinatal Intake of Polychlorinated Biphenyl (PCB)

    • Laura M. Juárez De Ku, Lee A. Meserve
    Pages 281-299

  12. Aluminum Exposure Produces Learning and Memory Deficits

    • Robert A. Yokel
    Pages 301-318

  13. Trimethyltin Neurotoxicity in the Rat as an Analogous Model of Alzheimer’s Disease

    • Michael L. Woodruff, Ronald H. Baisden
    Pages 319-335

  14. Back Matter

    Pages 337-344
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Keywords

About this book

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro­ toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni­ tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen­ cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro­ biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro­ degenerative disorders and assessing risk factors associated with neurotoxin ex­ posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.

Editors and Affiliations

  • East Tennesee State University, Johnson City, USA

    Michael L. Woodruff

  • Asbury College, Wilmore, USA

    Arthur J. Nonneman

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