Overview
- Editors:
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Umberto Bertazzoni
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CNR Institute of Biochemical and Evolutionary Genetics, Pavia, Italy
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F. J. Bollum
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Uniformed Services University of the Health Sciences, Bethesda, USA
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Table of contents (31 chapters)
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Structures and Properties of Terminal Deoxynucleotidyl Transferase
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- Tsuguhiro Kaneda, Saiko Kuroda, Osamu Koiwai, Shonen Yoshida
Pages 13-18
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- Hiromu Nakamura, Kazushi Tanabe, Shonen Yoshida, Mutsushi Matsuyama, Toshiteru Morita
Pages 19-23
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- Lucy M. S. Chang, F. J. Bollum
Pages 25-35
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- Martin R. Deibel Jr., Mary Sue Coleman, John J. Hutton
Pages 37-60
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- Claude Pénit, Maria-José Gelabert, Catherine Transy, Pierre Rouget
Pages 61-73
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- G. Damiani, E. Palla, V. Sgaramella, A. I. Scovassi, U. Bertazzoni
Pages 75-80
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- Shonen Yoshida, Sigeo Masaki, Hiromu Nakamura, Toshiteru Morita
Pages 81-85
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- Prakash Chandra, Ilhan Demirhan, Uwe Ebener
Pages 87-100
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Development of Immunological Reagents for Detection of Terminal Deoxynucleotidyl Transferase
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- Mary Sue Coleman, John J. Hutton
Pages 109-114
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Use of Terminal Deoxynucleotidyl Transferase as a Marker for Studies on Differentiation of Lymphocytes
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- G. Janossy, N. Tidman, K. F. Bradstock, A. V. Hoffbrand, F. J. Bollum
Pages 161-176
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- N. Sacchi, U. Bertazzoni, D. Breviario, P. Plevani, G. Badaracco, E. Ginelli
Pages 177-183
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- Claudio Casoli, Antonio Bonati, Riccardo Starcich
Pages 185-191
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- D. Breviario, P. Plevani, N. Sacchi, G. Badaracco, U. Bertazzoni, E. Ginelli
Pages 193-199
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About this book
This book contains the proceedings of a conference devoted to the study of the structure and function of Terminal deoxynucleotidyl Transferase (TdT) and its utilization as biochemical marker in immuno biology and leukemia, held in Elba, Italy on May 28-31, 1981. The en zyme has been known to nucleic acid biochemists for more than 20 years and has proved to be an excellent tool for making deoxypolymers, label ing DNA fragments, and adding homopolymer tails to restriction endonu clease fragments from DNA. Since the discovery of its peculiar tissue distribution, normally restricted to the thymus and bone marrow, and of its abnormal occur rence in human leukemic lymphoblasts, TdT has become one of the most widely used markers in the study of lymphocyte differentiation and in the classification of hematopoietic neoplasia. The subject seemed most appropriate for a meeting where molecular and cellular biologists, immunologists and hematologists could convene for the first time to discuss both basic research and the clinical aspects of the problem. Among the goals achieved by this workshop was the sharing of in formation about the enzymology of TdT, biochemical and immunological methodology and the correlation of TdT with other markers in the diag nosis of leukemia. The remarkable accordance of results, presented here by five independent hematological institutions, from analysis of TdT in several thousands of leukemic patients, marks the importance of this enzyme as a diagnostic and prognostic tool in these diseases.
Editors and Affiliations
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CNR Institute of Biochemical and Evolutionary Genetics, Pavia, Italy
Umberto Bertazzoni
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Uniformed Services University of the Health Sciences, Bethesda, USA
F. J. Bollum