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Terminal Transferase: Past to Present

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 145))

Abstract

It has been said that cells do not make proteins for irrelevant reasons. This means that every protein has a specific function. If we fail to understand that function the flaw is in human nature, not in Nature itself. A corollary of this logic is that if a unique kind of cell produces a unique protein, then that unique protein must be related to a special function of the unique class of cells. Terminal deoxynucleotidyl transferase (TdT) is such a protein, existing only in a limited population of lymphoid cells. The purpose of this meeting is to consider the phenomenology associated with the occurrence of this protein, and hopefully deduce Nature’s reason for producing it.

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References

  1. F. J. Bollum, J. Biol. Chem. 235:PC18–PC20 (1960).

    PubMed  CAS  Google Scholar 

  2. F. J. Bollum, J. Biol. Chem. 237:1945–1949 (1962).

    PubMed  CAS  Google Scholar 

  3. F. J. Bollum, E. Groeniger, and M. Yoneda, Proc. Natl. Acad. Sci. (USA) 51:853–859 (1964).

    Article  CAS  Google Scholar 

  4. J. S. Krakow, C. Coutsogeorgopoulous, and E. S. Cannellakis, Biochem. Biophys. Res. Commun. 5:477–481 (1961).

    Article  CAS  Google Scholar 

  5. F. J. Bollum in: “Procedures in Nucleic Acid Research” G. Cantoni, ed., Harper and Row, New York, pp 577–583 (1966).

    Google Scholar 

  6. K. Kato, J. M. Goncalves, G. E. Houts, and F. J. Bollum, J. Biol. Chem. 242:2780–2789 (1967).

    PubMed  CAS  Google Scholar 

  7. L. M. S. Chang and F. J. Bollum, J. Biol. Chem. 246:909–916 (1971).

    PubMed  CAS  Google Scholar 

  8. A. L. Shapiro, E. Vinuela, and J. V. Maizel, Jr., Biochem. Biophys. Res. Commun. 28:815–819 (1967).

    Article  PubMed  CAS  Google Scholar 

  9. L. M. S. Chang, Biochem. Biophys. Res. Commun. 44:124–131 (1971).

    Article  PubMed  CAS  Google Scholar 

  10. M. S. Coleman, J. J. Hutton, P. DeSimone, and F. J. Bollum, Proc. Natl. Acad. Sci. (USA) 71:4404–4408 (1974).

    Article  CAS  Google Scholar 

  11. R. P. McCaffery, D. F. Smoler, and D. Baltimore, Proc. Natl. Acad. Sci. (USA) 70:521–525 (1973).

    Article  Google Scholar 

  12. C. F. Lefler and F. J. Bollum, J. Biol. Chem. 244:594–601 (1969).

    PubMed  CAS  Google Scholar 

  13. F. J. Bollum, J. Biol. Chem. 234:2733–2734 (1959).

    PubMed  CAS  Google Scholar 

  14. L. M. S. Chang and F. J. Bollum, J. Biol. Chem. 246:5835–5847. (1971).

    PubMed  CAS  Google Scholar 

  15. L. M. S. Chang and F. J. Bollum, Biochemistry 11:1264–1272 (1972).

    Article  PubMed  CAS  Google Scholar 

  16. L. M. S. Chang, J. Biol. Chem. 248:3789–3795 (1973).

    PubMed  CAS  Google Scholar 

  17. P. S. Sarin and R. C. Gallo, J. Biol. Chem. 249:8051–8055 (1974).

    PubMed  CAS  Google Scholar 

  18. F. J. Bollum in: “Advances in Enzjnnology” A. Meister, ed., John Wiley and Sons, New York, Vol. 47, pp 347–374 (1978).

    Google Scholar 

  19. F. J. Bollum, Proc. Natl. Acad. Sei, (USA) 72:4119–4122 (1975).

    Article  CAS  Google Scholar 

  20. G. Janossy, J. A. Thomas, F. J. Bollum, S. Granger, G. Pizzolo, K. F. Bradstock, L. Wong, A. McMichael, K. Ganeshaguru, and A. V. Hoffbrand, J. Immunol. 125: 202–212 (1980).

    PubMed  CAS  Google Scholar 

  21. M. Sugimoto and F. J. Bollum, Immunol. 122:392–397 (1978).

    Google Scholar 

  22. K. F. Bradstock, G. Janossy, F. J. Bollum, and C. Milstein, Nature 284:455–457 (1980).

    Article  PubMed  CAS  Google Scholar 

  23. K. E. Gregoire, I. Goldschneider, R. W. Barton, and F. J. Bollum, J. Immunol. 123:1347–1352 (1979).

    PubMed  CAS  Google Scholar 

  24. R. Sasaki, F. J. Bollum, and I. Goldschneider, Immunol. 125:2501–2503 (1980).

    CAS  Google Scholar 

  25. F. J. Bollum, Blood 54:1203–1215 (1979).

    PubMed  CAS  Google Scholar 

  26. F. J. Bollum, Trends in Biochemical Sciences 6:41–43 (1981).

    Article  CAS  Google Scholar 

  27. F. J. Bollum and L. M. S. Chang, J. Biol. Chem. 256:8767–8770 (1981).

    PubMed  CAS  Google Scholar 

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© 1982 Plenum Press, New York

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Bollum, F.J. (1982). Terminal Transferase: Past to Present. In: Bertazzoni, U., Bollum, F.J. (eds) Terminal Transferase in Immunobiology and Leukemia. Advances in Experimental Medicine and Biology, vol 145. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8929-3_1

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  • DOI: https://doi.org/10.1007/978-1-4684-8929-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8931-6

  • Online ISBN: 978-1-4684-8929-3

  • eBook Packages: Springer Book Archive

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