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Effects of Biological Response Modifiers on the Growth and Differentiation of Terminal Deoxynucleotidyl Transferase Containing Lymphocytes

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Terminal Transferase in Immunobiology and Leukemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 145))

Abstract

The ability of certain biological response modifiers to induce the differentiation of lymphoid cells has been utilized to study the origins and developmental potentials of TdT+ cells, Most efforts have concerned the induction of T cell markers on TdT+ cells or the induction of TdT itself. The first successful experiments were conducted with bone marrow cells, but this approach has since been extended to cells from thymus and peripheral Iymphoid tissues. In addition, the role of growth regulating factors in the generation of TdT+ cells has been studied in vitro in cell and organ culture sytems. Relatively little work has been done on the induction of B cell markers on TdT+ cells, and vice versa. Therefore, the present report will be limited to a description of some of the effects of inducing agents on TdT+ members of the T cell lineage. For convenience, the discussion will be divided into considerations of prethymic, thymic and postthymic cells. A tentative synthesis of these results with the data from ontogenetic studies (see ref. 1, these Proceedings) will be attempted in the concluding remarks.

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  1. Department of Pathology, University of Connecticut Health Center, 06032, Farmington, Connecticut, USA

    Irving Goldschneider

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  1. CNR Institute of Biochemical and Evolutionary Genetics, Pavia, Italy

    Umberto Bertazzoni (CEC Official) (CEC Official)

  2. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

    F. J. Bollum

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Goldschneider, I. (1982). Effects of Biological Response Modifiers on the Growth and Differentiation of Terminal Deoxynucleotidyl Transferase Containing Lymphocytes. In: Bertazzoni, U., Bollum, F.J. (eds) Terminal Transferase in Immunobiology and Leukemia. Advances in Experimental Medicine and Biology, vol 145. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8929-3_13

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