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Diuretics: Basic, Pharmacological, and Clinical Aspects

Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986

  • V. E. Andreucci
  • Antonio Dal Canton

Part of the Developments in Nephrology book series (DINE, volume 18)

Table of contents

  1. Front Matter
    Pages i-lv
  2. Historical Review

    1. Front Matter
      Pages 1-1
    2. A. Dal Canton, M. Castellano
      Pages 3-8
  3. Effects of Diuretics on Ion Transport

    1. Front Matter
      Pages 9-9
    2. R. Greger, P. Wangemann, M. Wittner, A. Di Stefano, H. J. Lang, H. C. Englert
      Pages 33-38
    3. R. Garay, P. Hannaert, C. Nazaret, E. Deschamps De Paillette, G. Juin, P. Braquet
      Pages 50-52
    4. A. Montanari, A. Guerra, E. Sani, A. Novarini
      Pages 53-55
    5. J. Diez, I. Colina, J. Quiroga, R. Diaz-Tejeiro, L. Yap, F. Maduell et al.
      Pages 56-58
    6. R. Pedrinelli, A. Clerico, L. Graziadei, S. Taddei, M. Del Chicca, A. Salvetti
      Pages 59-61
    7. R. Boero, C. Guarena, F. Quarello, C. Rosati, B. Rolando, M. C. Deabate et al.
      Pages 62-64
    8. B. Baggio, G. Marzaro, G. Gambaro, F. Marchini, A. Borsatti, G. Clari
      Pages 65-67
    9. C. Guarena, R. Boero, C. Rosati, G. Forneris, G. Beltrame, F. Quarello et al.
      Pages 68-70
  4. Effects of Diuretics on Tubular Transport

    1. Front Matter
      Pages 71-71
    2. E. S. Stokke, J. Østensen, F. Kiil
      Pages 82-84
    3. F. Kiil, A. Hartmann, H. Langberg, O. M. Sejersted, M. Ree Holthe
      Pages 88-90
    4. S. Christensen, J. S. Petersen, E. Steiness, F. Andreasen
      Pages 91-94
    5. A. D’Angelo, A. Fabris, L. Malvasi, S. Giannini, R. Castrignano, A. Cecconello et al.
      Pages 95-97
  5. Pharmacokinetics

    1. Front Matter
      Pages 99-99
    2. P. Jungers, C. Divine, J. L. Durand, P. Y. Chambrin, Ph. Chauveau, T. Loubaris et al.
      Pages 101-103
    3. A. Dörfler, W. Schulz, Klinikum Bamberg III, W. Lahn, D. Hajdù
      Pages 104-106
    4. Per Sjöström, Bo Odlind, Björn Beermann, Margareta Hammarlund-Udenaes
      Pages 107-109
    5. E. v Moellendorff, E. Besenfelder, B. Kaufmann, G. Neugebauer
      Pages 110-112
    6. R. Faedda, G. F. Branca, G. Serra, A. Satta, E. Bartoli
      Pages 113-115
    7. J. Goeffroy, N. Ferry, N. Pozet, G. Cuisinaud, D. Benzoni, P. Y. Zech et al.
      Pages 116-118
  6. Endogenous Natriuretic Factors

    1. Front Matter
      Pages 123-123
    2. P. E. Chabrier, P. Roubert, I. Viossat, F. Rodrigue, M. Cantin, P. Braquet
      Pages 125-127
    3. C. Koseki, Y. Hayashi, M. Furuya, Y. Kanai, N. Ohnuma, M. Imai
      Pages 128-130
    4. J. P. Fluckiger, B. Waeber, G. Matsueda, J. Nussberger, H. R. Brunner
      Pages 131-133
    5. H. J. Kramer, J. Kipnowski, B. Stekle, A. Bäcker, H. Stelkens, H. G. Predel et al.
      Pages 134-136
    6. E. Hackenthal, R. E. Lang, C. P. Buhrle
      Pages 137-139
    7. P. Fievet, A. Fournier, A. De Bold, N. El Esper, P. Brunel, I. Gregoire
      Pages 145-147
    8. I. Tikkanen, C. Grönhagen-Riska, F. Fyhrquist
      Pages 148-150
    9. J. S. Petersen, O. M. Bech, E. Steiness, D. Kirstein, S. Christensen
      Pages 151-155
    10. G. Cannella, S. Ghielmi, A. Rodella, M. Gaggiotti, G. Brunori, M. Quinzanini et al.
      Pages 156-158
    11. H. Bobinski, J. C. Atherton, R. Green, L. Solomon
      Pages 159-161
    12. P. Hannaert, M. De Mendqnca, M. L. Grichois, B. Thormann, J. P. Abitbol, R. Garay
      Pages 162-164
    13. N. Frisina, M. Buemi, F. Squadrito, I. Macri’
      Pages 168-170
    14. Pierre Thievant, Joelle Baranes, Pierre Etienne Chabrier, Christine Guilmard, Sylvie Regnier, Pierre Braquet
      Pages 171-173
    15. P. Ferrari, H. E. de Wardener, J. A. Millet, L. Torielli, M. Ferrandi, G. Bianchi
      Pages 174-176

About this book

Introduction

The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car­ bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car­ bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.

Keywords

Drogen cardiovascular dopamine hypertension physiology transplantation

Editors and affiliations

  • V. E. Andreucci
    • 1
  • Antonio Dal Canton
    • 1
  1. 1.Department of NephrologyUniversity of NaplesNaplesItaly

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