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Neuropsychopharmacology of the Trace Amines

Experimental and Clinical Aspects

  • Book
  • © 1985

Overview

Editors:
  1. A. A. Boulton

    1. Psychiatric Research Division, Saskatchewan Health, University of Saskatchewan, Saskatoon, Canada

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  2. L. Maitre

    1. Research Department, CIBA-GEIGY AG, Basel, Switzerland

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  3. P. R. Bieck

    1. Human Pharmacology Institute, CIBA-GEIGY GmbH, Tübingen, Federal Republic of Germany

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  4. P. Riederer

    1. Ludwig-ßoltzmann Institut für klinische Neurobiologie, Krankenhaus Wien-Lainz, Wien, Austria

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Part of the book series: Experimental and Clinical Neuroscience (ECN)

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Table of contents (48 chapters)

  1. Front Matter

    Pages i-xv
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. The Trace Amines: Recent Overview and Future Pointers

      • Alan A. Boulton
      Pages 3-12

  3. Neuropsychopharmacology

    1. Front Matter

      Pages 13-13
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    2. Invited Communications

      1. Cerebral 2-Phenylethylamine Concentrations and Turnover not Influenced by Various Pharmacological Treatments in Rats
        • P. C. Waldmeier, A.-M. Buchle, J. Lauber
        Pages 15-26
      2. Pharmacological Profile of β-Phenylethylamine on Dopaminergic and Noradrenergic Neurotransmission in Rat Cerebral Slices : Comparison with Amphetamine and Other Trace Amines
        • Salomon Z. Langer, Sonia Arbilla, Ruth Niddam, Sanàa Benkirane, Patrice Baud
        Pages 27-38
      3. Further Investigation of the Metabolism of Two Trace Amines, β-Phenylethylamine and p-Tyramine by Rat Aorta Semicarbazide-Sensitive Amine Oxidase
        • C. Guffroy, T. Boucher, M. Strolin Benedetti
        Pages 39-50
      4. In Vivo Discriminative Stimulus (CUE) Properties in Rats of Beta-Phenylethylamine
        • A. J. Goudie, D. Reid
        Pages 51-62
      5. Effect of Psychoactive Drugs on Behavior Induced by 2-Phenylethylamine in Rats
        • R. Ortmann, M. Schaub, P. C. Waldmeier
        Pages 63-74
      6. Potentiation of the Biochemical Effects of β-Phenylethylamine and Tryptamine by Deuterium Substitution
        • L. E. Dyck, B. A. Davis, D. A. Durden, A. A. Boulton
        Pages 75-86
      7. Possible Pathways for Some Trace Amine-Containing Neurons
        • A. V. Juorio, A. J. Greenshaw, A. A. Boulton
        Pages 87-99
      8. [3H]Tryptamine Receptors in Rat Brain
        • P. L. Wood, L. L. Martin, C. A. Altar
        Pages 101-114
      9. Tryptamine, Tyramine and Histamine Immunoreactivities in Specific Neurones of the Gastropod CNS
        • N. N. Osborne
        Pages 115-124
      10. Behavioral and Pharmacological Characterisation of Tryptamine-Induced Excitation Syndrome in Rats
        • A. Delini-Stula, E. Radeke
        Pages 125-140
      11. Biosynthesis of β-Carbolines
        • Rudy Susilo, Hans Rommelspacher
        Pages 141-151
      12. Brain octopamine and strain Differences in Avoidance Behavior. Prenatal ontogenesis of phenolamines
        • J. C. David, J. Delacour, J. F. Coulon, C. Guenaire
        Pages 153-160
      13. Relations between MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine), the Neurotoxin MPP+ (1-Methyl-4-Phenylpyridinium Ion), and MAO in Rat Brain
        • Hiroyasu Kinemuchi, Yuichiro Arai, Yoshie Toyoshima, Takeshi Tadano, Kensuke Kisara
        Pages 161-171

    3. Free Communications

      1. Prodrugs of Trace Amines
        • Ronald T. Coutts, Glen B. Baker, Adil J. Nazarali, Tadimeti S. Rao, Ronald G. Micetich, T. W. Eric Hall
        Pages 175-180
      2. The Effect of Deuterium Labelling on Ionization Constants and Lipophilicity of Trace Amines
        • D. A. Durden
        Pages 181-186
      3. β-Phenylethylamine and Amphetamine Compared in Tests of Anorexia and Place-Preference Conditioning
        • D. B. Gilbert, S. J. Cooper
        Pages 187-193
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Keywords

About this book

A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto­ mated GC-MS. The methods are applied after separation of the sub­ stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues is in itself a remarkable technological achievement. The enormous task that several teams of research workers have set themselves is to investigate the origin of the trace amines, to understand their metabolism, and to discover whether or not they possess an important biological role. The 2nd Trace Amines Symposium at Weitenburg Castle near Tubingen from the 15th to the 19th May 1985 was held to gain a somewhat clearer insight into the present state of knowledge. Since the first meeting in 1983 our knowledge has increased and interest is deepening. Hence the idea proposed at that first meeting, of organizing similar gather­ ings at regular intervals, has come to fruition. Covered in the Neuropsychopharmacology section of this book are studiesof the effects of certain trace amines on different forms of be­ havior, on neurotransmission mediated by . the classical neuro­ transmitters, on their biosynthesis or on catabolism, on their possible occurrence as a result of alternative metabolic pathways for the amino acids, and in some instances their neuroanatomical distributions.

Editors and Affiliations

  • Psychiatric Research Division, Saskatchewan Health, University of Saskatchewan, Saskatoon, Canada

    A. A. Boulton

  • Research Department, CIBA-GEIGY AG, Basel, Switzerland

    L. Maitre

  • Human Pharmacology Institute, CIBA-GEIGY GmbH, Tübingen, Federal Republic of Germany

    P. R. Bieck

  • Ludwig-ßoltzmann Institut für klinische Neurobiologie, Krankenhaus Wien-Lainz, Wien, Austria

    P. Riederer

Bibliographic Information

  • Book Title: Neuropsychopharmacology of the Trace Amines

  • Book Subtitle: Experimental and Clinical Aspects

  • Editors: A. A. Boulton, L. Maitre, P. R. Bieck, P. Riederer

  • Series Title: Experimental and Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-1-4612-5010-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1985

  • Hardcover ISBN: 978-0-89603-099-2Published: 15 March 1986

  • Softcover ISBN: 978-1-4612-9397-2Published: 11 November 2011

  • eBook ISBN: 978-1-4612-5010-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 510

  • Topics: Psychiatry, Neurosciences

  • Industry Sectors: Biotechnology, Engineering, Health & Hospitals, Pharma

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