Abstract
A fundamental biological characteristic of Parkinson’s disease is a damaged dopamine (DA) system between the substantia nigra and the corpus striata. This disease is a slowly progressive-neurodegenerative disorder pathologically characterized by the loss of neurons in the zona compacta of the substantia nigra. The etiology of this disease has been extensively investigated, but the precise reason for the loss of DA producing cells in this region remains obscure. Previous animal models of this disease were made by nigrostriatal lesion, depletion of DA with reserpine or α-methyl-p-tyrosine, blockage of the DA receptor with neuroleptics such as haloperidol, destruction of the substantia nigra with 6-hydroxy-DA (see review, Zigmond and Striker, 1984) or manganese intoxication (Donaldson et al., 1982).
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Kinemuchi, H., Arai, Y., Toyoshima, Y., Tadano, T., Kisara, K. (1985). Relations between MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine), the Neurotoxin MPP+ (1-Methyl-4-Phenylpyridinium Ion), and MAO in Rat Brain. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_14
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DOI: https://doi.org/10.1007/978-1-4612-5010-4_14
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