An Integrative Approach From Science to Medicine

  • William D. Figg
  • Judah Folkman

Table of contents

  1. Front Matter
    Pages i-xix
  2. Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process

    1. Judah Folkman
      Pages 1-14
    2. M. Luisa Iruela-Arispe
      Pages 35-43
    3. Liliana Guedez, William G. Stetler-Stevenson
      Pages 55-62
    4. Alireza S. Alavi, David A. Cheresh
      Pages 63-73
  3. Angiogenesis and Regulatory Proteins

    1. Marco Presta, Stefania Mitola, Patrizia Dell'Era, Daria Leali, Stefania Nicoli, Emanuela Moroni et al.
      Pages 77-88
    2. Andrius Kazlauskas
      Pages 99-111
    3. Pipsa Saharinen, Lauri Eklund, Kari Alitalo
      Pages 113-120
    4. Michael B. Duncan, Raghu Kalluri
      Pages 121-127
  4. Molecular & Cellular Mechanisms of the Angiogenic Process

    1. Domenico Ribatti, Angelo Vacca
      Pages 161-168
    2. Philip J. S. Charlesworth, Adrian L. Harris
      Pages 169-179
    3. Donald P. Bottaro, Nelly Tan, W. Marston Linehan
      Pages 181-191
    4. L. Morbidelli, S. Donnini, M. Ziche
      Pages 193-204
    5. Harukiyo Kawamura, Xiujuan Li, Michael Welsh, Lena Claesson-Welsh
      Pages 205-216
    6. Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, John S. Rudge, Nicholas W. Gale et al.
      Pages 217-224

About this book


Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases.

This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters.

Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.


angiogenesis cell biology endothelium imaging regulation surgery tumor growth

Editors and affiliations

  • William D. Figg
    • 1
  • Judah Folkman
    • 2
  1. 1.Center for Cancer ResearchNational Cancer InstituteBethesdaUSA
  2. 2.Department of Surgery Harvard Medical School and Vascular Biology ProgramChildren's Hospital BostonBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer US 2008
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-0-387-71517-9
  • Online ISBN 978-0-387-71518-6
  • About this book
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