Hydrophilic Matrix Tablets for Oral Controlled Release

  • Peter Timmins
  • Samuel R. Pygall
  • Colin D. Melia

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 16)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Colin D. Melia, Peter Timmins
    Pages 87-122
  3. Lawrence M. Martin, Ali R. Rajabi-Siahboomi
    Pages 123-141
  4. Samuel R. Pygall, Simon R. Banks, Laura M. Mason, Gurjit S. Bajwa
    Pages 143-164
  5. Jonathan Brown, Sarah L. Hanley, Samuel R. Pygall, Paolo Avalle, Hywel D. Williams, Colin D. Melia
    Pages 165-189
  6. John McDermott, Peter Scholes, Wu Lin, Alyson Connor
    Pages 205-232
  7. Back Matter
    Pages 323-326

About this book


This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues.  Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.


cellulose ethers controlled release drug delivery excipient hydrophilic polymer systems

Editors and affiliations

  • Peter Timmins
    • 1
  • Samuel R. Pygall
    • 2
  • Colin D. Melia
    • 3
  1. 1.Drug Product Science and Technology, Bristol-Myers SquibbMoretonUnited Kingdom
  2. 2.Commercial Trade Channels, Merck, Sharp and DohmeHoddesdonUnited Kingdom
  3. 3.School of Pharmacy, University of NottinghamNotthinghamUnited Kingdom

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods