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An Industrial Perspective on Hydrophilic Matrix Tablets Based on Hyproxypropyl Methylcellulose (Hypromellose)

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Hydrophilic Matrix Tablets for Oral Controlled Release

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 16))

Abstract

This chapter explores the principal aspects that underpin the industrial design, formulation and manufacturing of hydroxypropyl methylcellulose (HPMC) matrix tablets. It shows how critical polymer attributes such as viscosity grade, substitution, particle size and batch consistency are important variables in matrix performance. The chapter also shows how the choice of excipients, manufacturing process and process variables can also influence matrix tablet properties. The careful control of drug, polymer, excipients and processing parameters is important in order to ensure an in-specification matrix performance. The role of tablet shape and coatings in tailoring drug release profiles is discussed.

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Authors and Affiliations

  1. GlaxoSmithKline GMS, Ware, Hertfordshire, UK

    Marina Levina Ph.D.

  2. Colorcon Global Headquarters, Harleysville, PA, USA

    Ali R. Rajabi-Siahboomi Ph.D.

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  1. Marina Levina Ph.D.
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  2. Ali R. Rajabi-Siahboomi Ph.D.
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Correspondence to Marina Levina Ph.D. .

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  1. Drug Product Science and Technology, Bristol-Myers Squibb, Moreton, Merseyside, United Kingdom

    Peter Timmins

  2. Commercial Trade Channels, Merck, Sharp and Dohme, Hoddesdon, Hertfordshire, United Kingdom

    Samuel R. Pygall

  3. School of Pharmacy, University of Nottingham, Notthingham, Nottinghamshire, United Kingdom

    Colin D. Melia

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Levina, M., Rajabi-Siahboomi, A.R. (2014). An Industrial Perspective on Hydrophilic Matrix Tablets Based on Hyproxypropyl Methylcellulose (Hypromellose). In: Timmins, P., Pygall, S., Melia, C. (eds) Hydrophilic Matrix Tablets for Oral Controlled Release. AAPS Advances in the Pharmaceutical Sciences Series, vol 16. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1519-4_3

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