Immunologic Defects in Laboratory Animals 1

  • M. Eric Gershwin
  • Bruce Merchant

Table of contents

  1. Front Matter
    Pages i-xx
  2. Defects of Immune Maturation

    1. Front Matter
      Pages 1-1
  3. Incomplete Immune Function in Normal Animals

    1. Front Matter
      Pages 17-17
    2. Denise Mouton, Claude Stiffel, Guido Biozzi
      Pages 19-47
  4. Immunohematologic Abnormalities

    1. Front Matter
      Pages 49-49
    2. Wieslaw Wiktor-Jedrzejczak, Regina R. Skelly, Aftab Ahmed
      Pages 51-77
    3. Saul J. Sharkis, Wieslaw Wiktor-Jedrzejczak, Aftab Ahmed
      Pages 79-97
    4. E. J. Brandt, R. T. Swank, E. K. Novak
      Pages 99-117
    5. William P. Hammond IV, David C. Dale
      Pages 119-136
  5. B-Cell Defects

    1. Front Matter
      Pages 137-137
    2. Albert A. Benedict, M. Eric Gershwin, Hans Abplanalp
      Pages 139-161
    3. Irwin Scher
      Pages 163-190
    4. Wanda Lizak Welles, Jack R. Battisto
      Pages 191-212
  6. T-Cell Defects

    1. Front Matter
      Pages 213-213
    2. Michael F. W. Festing
      Pages 267-283
    3. John L. O’Donoghue, Carolyn Reed
      Pages 285-296
    4. Kent L. Erickson, M. Eric Gershwin
      Pages 297-308
    5. Rene J. Duquesnoy, Grete M. Pedersen
      Pages 309-324
  7. Macrophage Defects

    1. Front Matter
      Pages 325-325
    2. Stefanie N. Vogel, Anita Corman Weinblatt, David L. Rosenstreich
      Pages 327-357
  8. Back Matter
    Pages 359-360

About this book


Tiselius demonstrated that the immunologically active components of immune sera migrated electrophoretically in the gamma globulin region. His findings illuminated the classic observations of Jenner regarding development of resistance to infection, and those of von Pirquet, Pasteur, and Arthus regarding the transfer and specificity of resistance. Conceptual integration of these observations provided the impetus for the present modern era of immunology. Subsequent to Tiselius's work, multiple, rapid advances have occurred in the study of congenital and acquired immune deficiency states in mice, chickens, and humans. These studies have readily demonstrated that the immunologic ability of an organ­ ism to protect itself from environmental influences is a prerequisite for survival. Indeed, this necessity for protection from microenvironmental influences has promoted the evolu­ tionary development of immunologic diversification, namely, host dependence upon a sophisticated, multifaceted network of cells and effector mechanisms responsible for the clearance and neutralization of toxins and potentially harmful pathogens. The obligate dependence of animals upon the functional integrity of their immunologic systems is illus­ trated by the ready invasion of ubiquitous organisms when the host is in a state of immune defense derangement. Nevertheless, derangements in immune function can range from par­ tial to complete and can be compatible with survival. The consequences of such derange­ ments run the gamut from subclinical disease to inevitable mortality.


Laboratory Mamma Tumor anatomy biology cells development immunology infection infectious disease mortality mouse pathology physiology resistance

Editors and affiliations

  • M. Eric Gershwin
    • 1
  • Bruce Merchant
    • 2
  1. 1.University of California School of MedicineDavisUSA
  2. 2.Food and Drug AdministrationBethesdaUSA

Bibliographic information