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Hematopoietic Stem Cell Differentiation and Its Role in Osteopetrosis

Immunologic Implications

  • Chapter
Immunologic Defects in Laboratory Animals 1

Abstract

Osteopetrosis is a mammalian disorder that is a consequence of a universal failure of bone remodeling processes. This disease results in an excessive accumulation of bone because of insufficient bone resorption and reformation (Gruneberg, 1938, 1963). Osteopetrosis is attributed to defective activity of osteoclasts; these cells are the primary cells involved in bone resorption and are now known to be derived from hematopoietic stem cells (Gothlin and Ericsson, 1976; Owen, 1978). The insight into the origin of the osteoclast and the experiments demonstrating that osteopetrosis could be cured by the transplantation of hematopoietic stem cells (Walker, 1975a-c) in some cases, and lymphoid T cells in other cases (Milhaud and Labat, 1978), demand that the relationship between the osteogenic, hematopoietic, and immunologic systems be examined. Such an evaluation, using osteopetrosis as a model, is the objective of this chapter.

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Authors and Affiliations

  1. Laboratory of Radiation Immunohematology, Military School of Medicine, Warsaw, Poland

    Wieslaw Wiktor-Jedrzejczak

  2. Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland, 20205, USA

    Regina R. Skelly

  3. Department of Immunology, Merck Institute for Therapeutic Research, Rahway, New Jersey, 07065, USA

    Aftab Ahmed

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  1. Wieslaw Wiktor-Jedrzejczak
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  2. Regina R. Skelly
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  3. Aftab Ahmed
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Editors and Affiliations

  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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© 1981 Plenum Press, New York

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Wiktor-Jedrzejczak, W., Skelly, R.R., Ahmed, A. (1981). Hematopoietic Stem Cell Differentiation and Its Role in Osteopetrosis. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_3

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