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Immunologic Defects in Laboratory Animals 1 pp 191–212Cite as

The Significance of Hereditary Asplenia for Immunologic Competence

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Abstract

Immunologic integrity results from a finely controlled balance of the cellular and molecular mechanisms that provide for surveillance, tolerance, and immunologic response. In recent years, as knowledge of these mechanisms has evolved, the spleen has emerged as an important regulatory organ that exerts myriad influences upon lymphocytes in situ as well as in other immunologic domains. This chapter, in addition to presenting a comprehensive view of splenic immunologic capability, will also focus on the concept that the spleen is influential to the maturation and function of lymphocytes within other immunologic sites (Battisto et al, 1971; Welles and Battisto, 1978, 1979). Both of these objectives will be achieved by examining studies of the hereditarily asplenic mouse, which provides a unique vehicle for the evaluation of splenic influences upon immunologic function.

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Author notes

  1. Wanda Lizak Welles

    Present address: Kidney Disease Institute, New York State Department of Health, Albany, New York, 12201, USA

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  1. Department of Immunology, Research Division, Cleveland Clinic Foundation, Cleveland, Ohio, 44106, USA

    Wanda Lizak Welles & Jack R. Battisto

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  1. Wanda Lizak Welles
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  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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Welles, W.L., Battisto, J.R. (1981). The Significance of Hereditary Asplenia for Immunologic Competence. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_9

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