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Athymic Nude Rats

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Book cover Immunologic Defects in Laboratory Animals 1

Abstract

The athymic nude (nu) mutation is now the most widely used of over 500 known mutations in the mouse. The virtual absence of any cell-mediated immune response in these animals has proved to be of great value both in the study of the immune system itself and as a tool in many areas of applied research, particularly in the study of cancer and infectious disease. Similar mutations in the rat and guinea pig should also be of value as tools in studying the immunobiology of these two species, and for research in which the mouse may not be entirely suitable (e.g., because of its small size). At the same time, study of these additional species should throw light on the generality of the observed biological effects of thymic aplasia in the mouse.

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Authors and Affiliations

  1. Medical Research Council Laboratory Animals Centre, Carshalton, Surrey, SM5 4EF, England

    Michael F. W. Festing

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  1. Michael F. W. Festing
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Editors and Affiliations

  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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© 1981 Plenum Press, New York

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Festing, M.F.W. (1981). Athymic Nude Rats. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_11

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  • DOI: https://doi.org/10.1007/978-1-4757-0325-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0327-6

  • Online ISBN: 978-1-4757-0325-2

  • eBook Packages: Springer Book Archive

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