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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2

Part A

  • Kenneth V. Honn
  • Santosh Nigam
  • Lawrence J. Marnett
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 400)

Table of contents

  1. Front Matter
    Pages i-xxv
    PDF

  2. Phospholipases

    1. Front Matter
      Pages 1-1
      PDF
    2. Regulation of Phosphoinositide Phospholipases by G-Proteins
      J. H. Exton
      Pages 3-8
    3. The Effects of Group II Phospholipase A2 on Ras-Induced Metastasis
      Thomas W. Davis, E. R. Boghaert, Carla J. Guthridge, Marion R. Steiner, Stephen G. Zimmer
      Pages 9-17
    4. Activation of Ca2+-Sensitive Cytosolic Phospholipase A2 (cPLA2) in Human Platelets
      Ruth M. Kramer, Edda F. Roberts, Joseph A. Jakubowski
      Pages 19-24
    5. Involvement of Reactive Oxygen Species in Phospholipase A2 Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases
      Rachel Goldman, Ernst Ferber, Uriel Zor
      Pages 25-30
    6. High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa
      A. S. Soydan, I. A. Tavares, P. K. Weech, N. M. Tremblay, A. Bennett
      Pages 31-37

  3. Biosynthetic Enzymes

    1. Front Matter
      Pages 39-39
      PDF
    2. (S)-Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the Dioxygenation Reaction
      Wolf D. Lehmann
      Pages 41-45
    3. Activation of 5-Lipoxygenase in Whole Polymorphonuclear Leukocytes by Arachidonic Acid: Evidence of Cytosolic Active Enzyme
      Luis Vila, Josep Sola
      Pages 47-56
    4. Intracellular Distribution, Activity, and Ca2+-Dependent Translocation of 12-Lipoxygenase in Lewis Lung Tumor Cells
      Wolfgang Hagmann, Robert Maher, Kenneth V. Honn
      Pages 57-64
    5. Cloning and Sequencing of Prostaglandin H Synthetase from Rat Tracheal Epithelial Cells: Structural Evidence that a TPA Regulated mRNA Codes for the Rat Ortholog of Murine PHS-1
      J. Kitzler, R. Hardman, E. Hill, N. Reddy, R. Philpot, T. E. Eling
      Pages 65-70
    6. Non-Enzymatic Rearrangement of Leukotriene A4 to 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid in Aqueous Media
      D. Riendeau, J.-P. Falgueyret, J. Gravel, L. Trimble, J. Yergey
      Pages 71-76
    7. Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H2 Synthase at Two Sites
      Mark S. Tang, Leslie J. Askonas, Trevor M. Penning
      Pages 77-84
    8. Regulation of Eicosanoid Synthesis in Liver Macrophages
      Petra Ambs, Edith Fitzke, Peter Dieter
      Pages 85-92
    9. Comparison of Arachidonic Acid Metabolism by Normal, Pre-Cancerous and Neoplastic Epithelial Cell Lines of the Upper Aerodigestive Tract
      Carl Snyderman, Donald Schwartz, Carrie Bonomi, Robin Wagner
      Pages 93-98
    10. Induction of Prostaglandin Endoperoxide Synthase-1 (Cox-1) in a Human Promonocytic Cell Line by Treatment with the Differentiating Agent TPA
      Christopher J. Smith, Jason D. Morrow, L. Jackson Roberts II, Lawrence J. Marnett
      Pages 99-106
    11. X-Ray Crystallographic Study of the Structure of Prostaglandin H Synthase
      Daniel Picot, Patrick J. Loll, R. Michael Garavito
      Pages 107-111
    12. Properties of Prostacyclin Synthase
      V. Ullrich, R. Brugger, F. Lottspeich, I. Siegle
      Pages 113-119
    13. Regulation of Prostaglandin H Synthase-1 Gene Expression
      Kenneth K. Wu
      Pages 121-126
    14. Mammalian Arachidonate 12-Lipoxygenases
      S. Yamamoto, Y. Takahashi, T. Hada, H. Hagiya, H. Suzuki, G. R. Reddy et al.
      Pages 127-131
    15. The Three-Dimensional Structure of Soybean Lipoxygenase-1: An Arachidonic Acid 15-Lipoxygenase
      Jeffrey C. Boyington, Betty J. Gaffney, L. Mario Amzel
      Pages 133-138
    16. Purification and Characterization of the Epidermal 8(S)Lipoxygenase
      M. Löschke, P. Kriec, W. D. Lehmann, F. Marks, G. Fürstenberger
      Pages 139-144
    17. The Effect of 5-Lipoxygenase-Activating Protein (Flap) on Substrate Utilization by 5-Lipoxygenase
      P. J. Vickers, C. Deluca, E. Wong, M. Abramovitz
      Pages 145-151
    18. Leukotriene A4 Hydrolase: Differential Inhibition of the Catalytic Activities by Divalent Cations
      Anders Wetterholm, Jesper Z. Haeggström
      Pages 153-157
    19. Regulation of 12(S)-Hete Production in Tumor Cells
      Yong Q. Chen, Wolfgang Hagmann, Kenneth V. Honn
      Pages 159-166
    20. Distribution of Cox-1 and Cox-2 in Normal and Inflamed Tissues
      Karen Seibert, Yan Zhang, Kathleen Leahy, Scott Hauser, Jaime Masferrer, Peter Isakson
      Pages 167-170
    21. Examination of Prostaglandin H Synthase-1 Topology in the Endoplasmic Reticulum Membrane
      Yong Ren, Christopher Walker, Ke-He Ruan, Richard J. Kulmacz
      Pages 171-175
    22. Coordinate Regulation of the Inducible forms of Prostaglandin Synthase and Nitric Oxide Synthase in Fibroblasts and Macrophages
      Harvey Herschman, Rebecca Gilbert, Srinivasa Reddy, Wei-Lin Xie
      Pages 177-182
    23. Molecular Cloning of Prostacyclin Synthase from Bovine Endothelial Cells
      T. Tanabe, S. Hara, A. Miyata, R. Brugger, V. Ullrich
      Pages 183-187
    24. Interaction of PGH Synthase Isozymes-1 and -2 with Nonsteroidal Anti-Inflammatory Drugs
      William L. Smith, Elizabeth A. Meade, David L. Dewitt
      Pages 189-196

  4. Receptors

    1. Front Matter
      Pages 197-197
      PDF
    2. Dual Effect of Propranolol on the Human Platelet Activation by Thrombin: Potentiation of Free Intracellular Ca2+ Mobilization and Inhibition of Phospholipase D Activity
      Stanislav I. Svetlov, Donald J. Hanahan
      Pages 199-205
    3. Molecular Diversity of Prostanoid Receptors; Subtypes and Isoforms of Prostaglandin E Receptor
      S. Narumiya
      Pages 207-213
    4. Molecular Characterization and Physiological Functions of PAF Receptors
      Haruhiko Bito, Takao Shimizu
      Pages 215-221
    5. Identification of the FP-Receptor as a Discrete Entity by Radioligand Binding in Biosystems that Exhibit Different Functional Rank Orders of Potency in Response to Prostanoids
      D. F. Woodward, C. E. Fairbairn, R. A. Lawrence
      Pages 223-227
    6. Cellular Activation by Thromboxane A2 and 8 — EPI — PGF2α
      Domenico Pratico, Dan O’Mahony, John Lawson, Therese Kinsella, Garret A. Fitzgerald
      Pages 229-233
    7. Modification on Ligand Binding to TXA2/PGH2 Receptors by Diethylpyrocarbonate
      Karsten Schrör, Karen Davis-Bruno, Perry V. Halushka
      Pages 235-240
    8. Prostaglandin Receptors Involved in Inflammatory Events
      R. L. Jones, R. A. Armstrong, H. Wise
      Pages 241-245
    9. LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs
      Patrick Y-K Wong, King-Teh Lin, Henry P. Godfrey
      Pages 247-251
    10. Isolation and Cloning of Human Peroxisome Proliferator Activated Receptor Gamma CDNA
      M. E. Greene, B. Blumberg, K. Kwan, L. Hsieh, G. L. Greene, S. D. Nimer
      Pages 253-260
    11. Structure and Localization of the Rabbit Prostaglandin EP3 Receptor
      Richard M. Breyer, Ronald B. Emeson, Linda S. Davis, Matthew D. Breyer
      Pages 261-268
    12. Prostaglandin Regulation of Gene Expression and Growth in Normal and Malignant Tissues
      M. Hughes-Fulford
      Pages 269-278
    13. Distinct Signaling Pathways Mediate Induction of c-fos by PGE2 in Glomerular Mesangial Cells
      Michael S. Simonson, William H. Herman, Michael J. Dunn
      Pages 279-286
    14. Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Binding Sites in Carcinoma Cells
      H. Herbertsson, S. Hammarström
      Pages 287-293

  5. Protein Kinases Phosphatases

    1. Front Matter
      Pages 295-295
      PDF
    2. Dag Second Messengers: Molecular Switches and Growth Control
      Andrew F.G. Quest, Sujoy Ghosh, Wen Qin Xie, Robert M. Bell
      Pages 297-303
    3. Sphingolipid Second Messengers: Tumor Suppressor Lipids
      Yusuf A. Hannun
      Pages 305-312
    4. The Role of Protein Kinase C in Signal Transduction, Growth Control and Lipid Metabolism
      I. Bernard Weinstein, Scott M. Kahn, Kevin O’driscoll, Christoph Borner, Ding Bang, Wei Jiang et al.
      Pages 313-321
    5. Tumor Responsiveness to the Metastasis-Stimulatory Effects of Prostaglandin E2 is Restricted by Protein Phosphatases
      M. R. I. Young, Y. Lozano, A. Djordjevic, G. D. Maier, M. E. Young
      Pages 323-328

About this book

Introduction

Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.

Keywords

apoptosis biology carcinogenesis cell cytokine cytokines metastasis prevention protein proteins receptor synthesis tumor

Editors and affiliations

  • Kenneth V. Honn
    • 1
  • Santosh Nigam
    • 2
  • Lawrence J. Marnett
    • 3
  1. 1.Wayne State UniversityDetroitUSA
  2. 2.Free University BerlinBerlinGermany
  3. 3.Vanderbilt UniversityNashvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-5325-0
  • Copyright Information Plenum Press, New York 1997
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7430-5
  • Online ISBN 978-1-4615-5325-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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