Abstract
Prostaglandin H2 (PGH) synthase (EC 1.14.99.1) catalyzes the bis-dioxygenation of arachidonic acid to yield PGG2 (cyclooxygenase reaction) and the peroxidative cleavage of PGG2 to yield PGH2 (peroxidase reaction). PGH synthase (Mr: 72 kDa) functions as a homodimer and is a target for nonsteroidal antiinflammatory drugs (NSAIDs), which inhibit the cyclooxygenase reaction only.
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Tang, M.S., Askonas, L.J., Penning, T.M. (1997). Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H2 Synthase at Two Sites. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_11
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DOI: https://doi.org/10.1007/978-1-4615-5325-0_11
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