Abstract
Metabolites of arachidonic acid (AA) have been implicated in the biologic behavior of squamous cell carcinoma of the head and neck (SCCHN). This hypothesis has generally been supported by three types of observations: 1) increased levels of AA metabolites in tumor tissues, 2) the effects of AA metabolites on tumor growth and/or host immune function, and 3) the effects of inhibitors of AA metabolism on tumor growth in vitro and in vivo. Much attention has been focused on prostaglandin E2 (PGE2) due to its multiple immunosuppressive effects. The importance of other cyclooxygenase and lipoxgenase metabolites has not been adequately addressed.
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© 1997 Springer Science+Business Media New York
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Snyderman, C., Schwartz, D., Bonomi, C., Wagner, R. (1997). Comparison of Arachidonic Acid Metabolism by Normal, Pre-Cancerous and Neoplastic Epithelial Cell Lines of the Upper Aerodigestive Tract. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_13
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DOI: https://doi.org/10.1007/978-1-4615-5325-0_13
Publisher Name: Springer, Boston, MA
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