Skip to main content
SpringerLink
Log in

High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa

  • Chapter
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 400))

Abstract

Human colon tumors usually produced more prostaglandins compared with associated normal mucosa (Bennett et al. 1987) but the reason is not well understood. Lipid peroxidation, phospholipase A2 activity and myeloperoxidase activity were increased in colorectal cancers compared with macroscopically normal tissues (Otamiri et al. 1989). Varying amounts of total arachidonic acid in the phospholipids of colorectal tumors compared to normal associated mucosa have been reported (Yazici et al. 1991; Neoptolemos et al. 1991).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bennett, A., Civier, A., Hensby, C.N., Melhuish, P.B. and Stamford, I.F. Gut, 28:315–318, 1987.

    Article  PubMed  CAS  Google Scholar 

  2. Channan, J.Y. and Leslie, C.C. J. Biol. Chem. 265:5409–5413, 1990.

    Google Scholar 

  3. Clark, J.D., Lin, L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, N. and Knopf, J.L. Cell 65:1043–1051, 1991.

    Article  PubMed  CAS  Google Scholar 

  4. Hara, S., Kudo, I., Chang, H.W., Matsuta, T. and Inoue, K. J. Biochem., 105:395–399, 1989.

    PubMed  CAS  Google Scholar 

  5. Kudo, I., Murakami, M., Hara, S. and Inoue, K. Biochim. Biophys. Acta, 1170:217–231, 1993.

    Article  PubMed  CAS  Google Scholar 

  6. Laemmli, U.K. Nature, 227:680–685, 1970.

    Article  PubMed  CAS  Google Scholar 

  7. Neoptolemos, J.P., Husband, D., Imray, C., Rowley, S. and Lawson, N. Gut, 32:278–281, 1991.

    Article  PubMed  CAS  Google Scholar 

  8. Yazici, Z., Tavares, I.A., Bishai, P.M. and Bennett, A. In: Prostaglandins, Leukotrienes, Lipoxins and PAF. XI The Washington International Spring Symposium, USA, Abstract pp. 268; 1991.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, The Rayne Institute, King’s College School of Medicine and Dentistry, London, SE5 9NU, UK

    A. S. Soydan, I. A. Tavares & A. Bennett

  2. Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, H9R 4P8, Quebec, Canada

    P. K. Weech & N. M. Tremblay

Authors
  1. A. S. Soydan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. A. Tavares
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. K. Weech
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. M. Tremblay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Free University Berlin, Berlin, Germany

    Santosh Nigam

  3. Vanderbilt University, Nashville, Tennessee, USA

    Lawrence J. Marnett

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Soydan, A.S., Tavares, I.A., Weech, P.K., Tremblay, N.M., Bennett, A. (1997). High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5325-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7430-5

  • Online ISBN: 978-1-4615-5325-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation