Table 23.2 Reactive groups that can covalently react with the catalytically active serine.
From: Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
Inhibitor type | Functional group | |
|---|---|---|
Irreversible | Chloromethylketone | –COCH2Cl |
Sulfonylfluoride | –SO2F | |
Estera | –COOR | |
Boronic acida | –B(OR)2 | |
Reversible | Aldehyde | –CHO |
Ketone | –COR (R = Alkyl, –Aryl) | |
Trifluoromethylketone | –COCF3 | |
α-Ketocarboxylic acid | –COCOOH | |
α-Ketoamide | –COCONHR | |
α-Ketoester | –COCOOR |