Fig. 23.18
From: Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
Crystal structure of rivaroxaban 23.31 (Fig.23.19) in factor Xa. The inhibitor’s chlorothiophene group binds in the deep S1 pocket, at the end of which Tyr228 and Asp189 are found. The chlorine atom forms interactions with the aromatic rings. The phenyl ring and the terminal lactam ring of the inhibitor are found in the S3 pocket, which is enclosed by the three aromatic groups of Tyr99, Phe174, and Trp215.