Abstract
Attaining desired blood drug concentration and, consequently, augmenting the bioavailability of poorly absorbed drugs have always been an essential aspect for the pharmaceutical agency. The achievement of this target gives positive economic benefits as reducing drug dosage and medical impacts in decreasing toxicity and bacterial resistance in case of antimicrobials. Various factors may reduce the availability of drugs. There are numerous ways to estimate bioavailability. Various software’s models have been developed to simplify such analyses. The newly developed programs should provide a range of modules for pharmacokinetic and pharmacodynamic analysis with a more user-friendly interface.
Attaining desired blood drug concentration and, consequently, augmenting the bioavailability of poorly absorbed drug molecules have always been an essential aspect of development plans for the pharmaceutical agency. The achievement of this target gives positive economic benefits as reducing drug dosage and frequency and medical impacts in decreasing toxicity and bacterial resistance in case of antimicrobials. A drug may be well absorbed orally because of good lipid solubility and yet not has a good oral bioavailability because of extensive presystemic loss. Various physiological factors reduce the availability of drugs prior to their entry into the systemic circulation. There are numerous ways that are followed to estimate bioavailability. To simplify such analyses, various software’s models have been developed. The newly developed programs should provide a range of modules for pharmacokinetic and pharmacodynamic analysis with a more user-friendly interface. Factors that reduce the availability of drugs prior to their entry into the systemic circulation should be considered during prescription. Understanding the difference between absolute and relative bioavailability and be able to convert between these values is an essential issue. Relative bioavailability is one of the significant measures used to assess bioequivalence between several drug products.
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Abo-EL-Sooud, K. (2018). Absolute and Relative Bioavailability. In: Hock, F., Gralinski, M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-56637-5_16-2
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DOI: https://doi.org/10.1007/978-3-319-56637-5_16-2
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Absolute and Relative Bioavailability- Published:
- 03 May 2018
DOI: https://doi.org/10.1007/978-3-319-56637-5_16-2
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Absolute and Relative Bioavailability- Published:
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DOI: https://doi.org/10.1007/978-3-319-56637-5_16-1