Synonyms
Definition
Bradykinesia is the cardinal symptom of Parkinson’s disease (PD). It is related to an abnormal slowness of movement. The causes of PD bradykinesia are not known largely, because there are multiple brain areas and pathways involved from the neuronal degeneration site (dopamine (DA) neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles (see Fig. 1). Bradykinesia models are mathematical and computational constructs attempting to uncover how information is processed in the affected brain areas and what are the biophysical mechanisms giving rise to the observed slowness of movement in PD bradykinesia.
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Further Reading
Scholarpedia
Basal Ganglia
Dopamine Anatomy
Models of Basal Ganglia
Models of Parkinson’s Disease Bradykinesia
Models of Spinal Cord
Models of Thalamocortical System
Wikipedia
Hypokinesia
Motor Control
Motor System
Parkinson’s Disease
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Cutsuridis, V. (2018). Basal Ganglia: Bradykinesia Models. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_85-2
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_85-2
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Basal Ganglia: Bradykinesia Models- Published:
- 01 September 2018
DOI: https://doi.org/10.1007/978-1-4614-7320-6_85-2
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_85-1