Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Bradykinesia Models

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_85-1

Synonyms

Definition

Bradykinesia is the cardinal symptom of Parkinson’s disease (PD). It is related to an abnormal slowness of movement. The causes of PD bradykinesia are not known largely, because there are multiple brain areas and pathways involved from the neuronal degeneration site (dopamine neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles. Bradykinesia models are mathematical and computational constructs attempting to uncover how information is processed in the affected brain areas and what are the biophysical mechanisms giving rise to the observed slowness of movement in PD bradykinesia.

Detailed Description

Bradykinesia, the hallmark and most disabling symptom of PD, refers to an extreme slowness of movement. In early stages of the disease, PD patients have difficulties with daily activities such as walking, speaking, or getting in and out of chairs (Gibberd 1986). In the later phases...

Keywords

Dopamine 
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Further Reading: Scholarpedia

  1. Basal GangliaGoogle Scholar
  2. Dopamine AnatomyGoogle Scholar
  3. Models of Basal GangliaGoogle Scholar
  4. Models of Parkinson’s Disease BradykinesiaGoogle Scholar
  5. Models of Spinal CordGoogle Scholar
  6. Models of Thalamocortical SystemGoogle Scholar

Further Reading: Wikipedia

  1. HypokinesiaGoogle Scholar
  2. Motor ControlGoogle Scholar
  3. Motor SystemGoogle Scholar
  4. Parkinson’s DiseaseGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - HellasHeraklion, CreteGreece