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Table of contents

  1. Front Matter
    Pages 1-27
  2. The “Modus Operandi” of Regulatory Toxicology

    1. Front Matter
      Pages 1-2
    2. Michael Schwenk, H. Paul A. Illing
      Pages 21-30
    3. Dietrich Henschler, Wolfgang Dekant
      Pages 49-55
    4. Werner Lilienblum, Stephen Harston
      Pages 57-63
    5. Maged Younes
      Pages 65-71
  3. Approaches Used

    1. Front Matter
      Pages 73-74
    2. Karl Georg Heimann, Kevin Doughty
      Pages 81-88
    3. Wolfgang Kaufmann, Matt C. Jacobsen
      Pages 89-98
    4. Eckhard von Keutz
      Pages 107-113
    5. Thomas Steger-Hartmann, Scott Boyer
      Pages 123-131
    6. Gert Ulrich Kuerzel, Christine Mauriac
      Pages 133-139
    7. Jürgen Pauluhn
      Pages 141-160
    8. Dieter Schrenk
      Pages 161-172
    9. Heidrun Ellinger-Ziegelbauer, Hans-Juergen Ahr
      Pages 173-179
    10. Ulrich Ranft, Gregory A. Wellenius
      Pages 191-205
    11. Klaus Mörike
      Pages 207-212
    12. Ludwig A. Hothorn
      Pages 213-223
    13. Odile Mekel, Rainer Fehr
      Pages 253-259
    14. Lutz Edler, Angelika Tritscher
      Pages 261-268
    15. Johannes Georg Filser
      Pages 269-276
    16. Gerhard Volland
      Pages 277-288
    17. Gerhard Heinemeyer
      Pages 289-304
    18. Klaus Schneider, Agnieszka Kinsner-Ovaskainen, Martin Hassauer
      Pages 305-309
    19. Inge Mangelsdorf
      Pages 311-319
    20. Jürgen Durner, David C. Watts
      Pages 321-357
    21. Lutz Edler
      Pages 359-375
    22. Michael Schümann, Özkaynak Haluk, Alexandre Zenié
      Pages 377-394
  4. Paradigms used in Risk Evaluation

    1. Front Matter
      Pages 395-396
    2. Bernd Kaina, Adam D. Thomas, Jan G. Hengstler
      Pages 397-406
    3. Thomas R. H. Büch, Eva A. M. Schäfer, John H. Duffus, Thomas Gudermann
      Pages 407-411
    4. Manfred Ruthsatz, Carlo Chiavaroli, Emmanuelle Voisin
      Pages 413-422
    5. Rainer Konietzka, Klaus Schneider, Leonard Ritter
      Pages 431-438
    6. Norbert Englert, Robert L. Maynard
      Pages 449-455
    7. Ursula Gundert-Remy
      Pages 457-461
    8. Ludwig Müller, Neill H. Stacey
      Pages 463-467
    9. Bernhard Liebl, Ines Liebl
      Pages 475-480
    10. Beate Henrikus, Wolfgang Eisenmenger
      Pages 481-490
  5. Risk Assessment and Evaluation

    1. Front Matter
      Pages 491-492

About this book

Introduction

This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.  Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Keywords

environmental and occupational health exposure analysis regulatory toxicology risk assessment risk management and communication toxicological test procedures

Editors and affiliations

  • Franz-Xaver Reichl
    • 1
  • Michael Schwenk
    • 2
  1. 1.Walther-Straub-Institute of Pharmacology and ToxicologyLMU MunichMunichGermany
  2. 2.Formerly Medical SchoolHannoverGermany

Bibliographic information

Industry Sectors
Pharma
Chemical Manufacturing
Biotechnology
Consumer Packaged Goods