Abstract
Toxicological tests are only meaningful and interpretable, when the chemical composition and the physicochemical properties of the applied substances are known. These properties determine to a large extent the behaviour of a substance in the environment and in the living organism. Thus knowledge of physicochemical properties is important for the development of therapeutic drugs as well as for the risk assessment of all chemicals.
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References
European Medicines Agency (2007) Guideline on the clinical investigation of the pharmacokinetics of therapeutic proteins
Jefferis R (2011) Aggregation, immune complexes and immunogenicity. MAbs 3(6):503–504. doi: 10.4161/mabs.3.6.17611. Epub 2011 Nov 1
Krämer SD, Wunderli-Allenspach H (2001) Physicochemical properties in pharmacokinetic lead optimization. Farmaco 56(1–2):145–148
Swami R, Shahiwala A (2013) Impact of physiochemical properties on pharmacokinetics of protein therapeutics. Eur J Drug Metab Pharmacokinet
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Locher, M. (2014). Characterization of Physicochemical Parameters in Toxicology. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35374-1_30
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DOI: https://doi.org/10.1007/978-3-642-35374-1_30
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35373-4
Online ISBN: 978-3-642-35374-1
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