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Toxicological Risk Assessment

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Regulatory Toxicology

Abstract

Risk analysis encompasses the scientific review and evaluation of all relevant scientific data on the toxicity of, and the exposure to, a certain compound or mixture. To enable a systematic analysis of the different types of information needed, various risk analysis paradigms have been developed. Among these, the scheme developed in 1983 by the US National Academy of Sciences (NAS) has been the most widely utilized. Risk analysis provides the scientific basis for regulatory actions within the context of risk management.

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Recommended Reading

  • European Commission, Environment Directorate General (2007) REACH in Brief. http://ec.europa.eu/environment/chemicals/reach/pdf/2007_02_reach_in_brief.pdf

  • National Research Council (1983) Risk assessment in the federal government: managing the process. National Academy Press, Washington, DC

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  • National Research Council (1993) Issues in risk. National Academy Press, Washington, DC

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  • National Research Council (2009) Science and decisions: advancing risk assessment. National Academy Press, Washington, DC

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  • World Health Organization (1999) Principles of the assessment of risks to human health from exposure to chemicals. Environmental Health Criteria 210. WHO, Geneva

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  • Younes M, Meek ME, Hertel RF, Gibb H, Schaum J (1999) Risk assessment and management. In: Herzstein JA, Bunn WB, Fleming LE, Harrington JM, Jeyaratnam J, Gardner IR (eds) International occupational and environmental medicine. Mosby, St. Louis, p 62

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Author information

Authors and Affiliations

  1. Former Director, Food Safety and Zoonoses, World Health Organization (WHO), Chemin sous voic 14B, Mies, Switzerland

    Maged Younes

Authors
  1. Maged Younes
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Correspondence to Maged Younes .

Editor information

Editors and Affiliations

  1. Walther-Straub-Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany

    Franz-Xaver Reichl

  2. Formerly Medical School, Hannover, Germany

    Michael Schwenk

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© 2014 Springer-Verlag Berlin Heidelberg

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Younes, M. (2014). Toxicological Risk Assessment. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35374-1_29

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