Oncogenic Signaling of Tyrosine Kinase in Cancer: Challenges and Therapeutic Opportunities

In this topical collection (34 articles)

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1. Review

   Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities

   Emily K. Kleczko, Lynn E. Heasley Article:60

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2. Review

   Mechanisms of receptor tyrosine kinase activation in cancer

   Zhenfang Du, Christine M. Lovly Article:58

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3. Review

   Role of Bruton’s tyrosine kinase in B cells and malignancies

   Simar Pal Singh, Floris Dammeijer, Rudi W. Hendriks Article:57

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4. Review

   Non ABL-directed inhibitors as alternative treatment strategies for chronic myeloid leukemia

   Michele Massimino, Stefania Stella, Elena Tirrò, Chiara Romano… Article:56

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5. Review

   Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors

   Wagner Ricardo Montor, Andrei Ronaldo Oliveira Silva Escartin Salas… Article:55

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6. Review

   Expression, regulation and targeting of receptor tyrosine kinases in esophageal squamous cell carcinoma

   Manoj Kumar Kashyap, Omar Abdel-Rahman Article:54

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7. Review

   EGFR-TKIs resistance via EGFR-independent signaling pathways

   Qian Liu, Shengnan Yu, Weiheng Zhao, Shuang Qin, Qian Chu, Kongming Wu Article:53

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8. Review

   The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

   Brandon Golding, Anita Luu, Robert Jones, Alicia M. Viloria-Petit Article:52

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9. Review

   Novel targeted therapies and immunotherapy for advanced thyroid cancers

   George E. Naoum, Michael Morkos, Brian Kim, Waleed Arafat Article:51

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10. Research

    Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

    Ho Jin Lee, Phuong Chi Pham, Seung Yeob Hyun, Byungyeob Baek… Article:50

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11. Review

    Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy

    Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo… Article:49

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12. Review

    Kinase-targeted cancer therapies: progress, challenges and future directions

    Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan… Article:48

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13. Research

    CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer

    Jennifer Pasquier, Marie Gosset, Caroline Geyl, Jessica Hoarau-Véchot… Article:47

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14. Review

    The rationale for druggability of CCDC6-tyrosine kinase fusions in lung cancer

    Aniello Cerrato, Roberta Visconti, Angela Celetti Article:46

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15. Review

    Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

    Yazhuo Zhang, Mengfang Xia, Ke Jin, Shufei Wang, Hang Wei, Chunmei Fan… Article:45

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16. Research

    miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer

    Ulrich Baumgartner, Fabienne Berger, Ali Hashemi Gheinani… Article:44

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17. Review

    Targeting tumour microenvironment by tyrosine kinase inhibitor

    Hor-Yue Tan, Ning Wang, Wing Lam, Wei Guo, Yibin Feng, Yung-Chi Cheng Article:43

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18. Research

    Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer

    Yuan-Chin Tsai, Tao Zeng, Wassim Abou-Kheir, Hsiu-Lien Yeh… Article:42

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19. Review

    Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemia

    Stefania Rocca, Giovanna Carrà, Pietro Poggio, Alessandro Morotti… Article:40

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20. Review

    The role of RICTOR downstream of receptor tyrosine kinase in cancers

    Ahlem Jebali, Nicolas Dumaz Article:39

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