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    In Vitro Evaluation of Serine Hydrolase Inhibitors

    Serine hydrolases are important in a variety of physiological processes and can be important pharmacological and toxicological molecular targets. A modified photometric method suitable for evaluating inhibitio...

    Carey Pope, Kirstin Hester, Lester Sultatos (2018)

  2. No Access

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    Drosophila as a Neurotoxicological Model

    Drosophila melanogaster is a powerful model genetic system widely used for a variety of neurobiological and developmental studies. Its use for neurotoxicological experiments has been relatively limited but is now...

    Hakeem O. Lawal, David E. Krantz (2018)

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    Computational Predictions for Multi-Target Drug Design

    Computational techniques have proven to be an essential tool in modern drug discovery research. These tools offer powerful methods for prediction of ligand–receptor interaction events at atomic details, withou...

    Neelima Gupta, Prateek Pandya, Seema Verma (2018)

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    Identification of Natural Product Biosynthetic Gene Clusters from Bacterial Genomic Data

    The frequent re-isolation of known compounds is one of the main challenges of traditional screening methods for natural products drug discovery. The ability to connect natural products to the genes that encode...

    Alessandra S. Eustáquio, Nadine Ziemert (2018)

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    Determining Competitive Potential of Bone Metastatic Cancer Cells in the Murine Hematopoietic Stem Cell Niche

    The ability of cancer cells to compete with hematopoietic stem cells (HSCs) to target the bone marrow microenvironment, or the HSC niche, during the dissemination process is critical for the development of bon...

    Sun H. Park, Matthew R. Eber, Russell S. Taichman, Yusuke Shiozawa (2018)

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    Cultivation of Adipose-Derived Stromal Cells on Intact Amniotic Membrane-Based Scaffold for Skin Tissue Engineering

    Application of cell-based skin substitutes has recently evolved as a novel treatment for hard-to-heal wounds. Here, we focus on the development of a novel skin substitute by seeding human adipose-derived strom...

    Ehsan Taghiabadi, Bahareh Beiki, Nasser Aghdami, Amir Bajouri (2018)

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    Functional Assays of Stem Cell Properties Derived from Different Niches

    It has been described that adult tissues contain mesenchymal stem cell populations. The specific areas where stem cells reside are known as niches. Crosstalk between cells and their niche is essential to maint...

    Beatriz de Lucas, Laura M. Pérez, Beatriz G. Gálvez (2018)

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    Computational Studies on Natural Products for the Development of Multi-target Drugs

    Secondary plant metabolites represent “privileged structures” in drug development; they frequently interact with multiple protein targets within the body. For example, the anti-inflammatory natural product res...

    Veronika Temml, Daniela Schuster (2018)

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    In Vitro and In Vitro Models for Alcohol Toxicity to the Extracellular Matrix of Astrocytes

    Ethanol exposure exerts profound effects on the developing brain, which lead to cognitive impairment and behavioral functional disorders as seen in fetal alcohol spectrum disorders (FASD). Astrocytes play a ma...

    Xiaolu Zhang, Marina Guizzetti (2018)

  10. No Access

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    In Vitro Approaches for Studying Amyloids and Neurotoxicity

    Several neurodegenerative diseases are protein conformational disorders, characterized by protein misfolding events. Misfolded proteins can aggregate or form amyloids in vivo, interfering with normal protein f...

    Aseel Eid, Shannon E. May, Nasser Zawia, Jodi L. Camberg (2018)

  11. No Access

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    Computational Methods for Multi-Target Drug Designing Against Mycobacterium tuberculosis

    Despite the availability of several drugs, Mycobacterium tuberculosis is still a big concern for public health. Such situation exists because of continuous emergence of TB-resistant strains. Possible reasons of d...

    Gaurava Srivastava, Ashish Tiwari, Ashok Sharma (2018)

  12. No Access

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    Computational Multi-Target Drug Design

    Multi-target (mt) therapy is an attractive approach as well as a challenging task in drug discovery research and pharmaceutical industry. The multi-target drug design strategy is an opportunity to find new dru...

    Azizeh Abdolmaleki, Fereshteh Shiri, Jahan B. Ghasemi (2018)

  13. No Access

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    Computational Design of Multitarget Drugs Against Alzheimer’s Disease

    In the present review, the authors provide the basic background about the molecular targets implicated in the pathogenesis of Alzheimer’s disease. Furthermore, the authors review structure–activity relationshi...

    Sotirios Katsamakas, Dimitra Hadjipavlou-Litina (2018)

  14. No Access

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    Computational Method for Prediction of Targets for Breast Cancer Using siRNA Approach

    The increasing incident of breast cancer, which is a leading cause of women’s death in both developed and developing countries, demands the development of novel and efficient therapies. One of the major challe...

    Atul Tyagi, Mukti N. Mishra, Ashok Sharma (2018)

  15. No Access

    Protocol

    Computational Design of Multi-Target Drugs Against Breast Cancer

    One drug one target approach has nowadays evolved in the form of one drug multiple targets strategy for the drug designing. In recent years, polypharmacology has gained much attention for the identification of...

    Shubhandra Tripathi, Gaurava Srivastava, Ashok Sharma (2018)

  16. No Access

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    Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease

    Alzheimer’s disease (AD) is a complex neurodegenerative disorder with a multi-faceted pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and despite enormous efforts to elucida...

    Cindy Juliet Cristancho Ortiz, Matheus de Freitas Silva, Vanessa Silva Gontijo (2018)

  17. No Access

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    Networking of Smart Drugs: A Chem-Bioinformatic Approach to Cancer Treatment

    Increasing rate of cancer incidence has put a global demand of high and advanced level of diagnosis methods. Although surgery (surgical treatment), radiotherapy, and chemotherapy are well-known traditional met...

    Kavindra Kumar Kesari, Qazi Mohammad Sajid Jamal, Mohd. Haris Siddiqui (2018)

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    Molecular Docking Studies in Multitarget Antitubercular Drug Discovery

    Tuberculosis, caused by Mycobacterium tuberculosis, is an infectious disease with high levels of mortality worldwide, currently with approximately 6.3 million new cases per year that often present resistance to b...

    Jéssika de Oliveira Viana, Marcus T. Scotti, Luciana Scotti (2018)

  19. No Access

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    Mitochondrial Redox Sensor for Drosophila Female Germline Stem Cells

    Mitochondrial reactive oxygen species (mROS), a major source of ROS within cells, functions as an important signaling molecule and has the ability to damage cellular macromolecules including DNA and proteins. ...

    Kiran Suhas Nilangekar, Bhupendra V. Shravage (2018)

  20. No Access

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    Isolation and Characterization of Cutaneous Epithelial Stem Cells

    The outer layer of mammalian skin is a multilayered epithelium that perpetually renews multiple differentiated lineages. During homeostasis, the maintenance of skin epithelial turnover is ensured by regionaliz...

    Stephanie R. Gillespie, David M. Owens (2018)

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