Theme: Use of PBPK Modeling to Inform Clinical Decisions: Current Status of Prediction of Drug-Food Interactions

In this topical collection (7 articles)

1. 

   Research Article

   Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection

   Monika Gajewska, Lars Blumenstein, Alexandros Kourentas… Article:134

2. 

   Research Article

   Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

   Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas… Article:126

3. Research Article

   Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

   Arian Emami Riedmaier, Kevin DeMent, James Huckle, Phil Bransford… Article:123

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4. 

   Research Article

   Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug–Food Interactions: Recommendations for Improving Predictive Performance of Low Confidence Food Effect Models

   Christian Wagner, Filippos Kesisoglou, Xavier J. H. Pepin, Neil Parrott… Article:85

5. 

   Research Article

   Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib

   Neil Parrott, Cordula Stillhart, Marc Lindenberg, Bjoern Wagner… Article:78

6. 

   Review Article

   Does Food Affect the Pharmacokinetics of Non-orally Delivered Drugs? A Review of Currently Available Evidence

   Peng Zou Article:59

7. 

   Research Article

   Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach

   Xavier J. H. Pepin, James E. Huckle, Ravindra V. Alluri, Sumit Basu… Article:12