Table of contents

  1. Front Matter
    Pages i-xxviii
  2. G. N. Cohen
    Pages 1-12
  3. G. N. Cohen
    Pages 31-58
  4. G. N. Cohen
    Pages 59-71
  5. G. N. Cohen
    Pages 127-138
  6. G. N. Cohen
    Pages 139-145
  7. G. N. Cohen
    Pages 147-152
  8. G. N. Cohen
    Pages 153-177
  9. G. N. Cohen
    Pages 179-193
  10. G. N. Cohen
    Pages 195-204
  11. G. N. Cohen
    Pages 205-217
  12. G. N. Cohen
    Pages 219-225
  13. G. N. Cohen
    Pages 227-234

About this book

Introduction

This book focuses on microbial physiology, biochemistry, and genetics and provides the reader with detailed information on a number of microbial pathways. Insight into microbial biochemistry allows for the formulation of concepts which have turned out to be important in the study of higher organisms.

In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery which is indispensable for the comprehension of many regulatory mechanisms described throughout the book.

The second section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation.

The fifteen chapters after that deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12.

The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.

Keywords

Biosynthetic Pathways Permeability Regulation Archaea

Authors and affiliations

  • G. N. Cohen
    • 1
  1. 1.Institut de Génomique (Commissariat à l’Energie Atomique)Institut de Génomique (Génoscope) du Commissariat à l’Energie Atomique, Evry, France, Centre National de la Recherche Scientifique, Paris, France, Institut PasteurParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-8908-0
  • Copyright Information Springer Science+Business Media B.V. 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-8907-3
  • Online ISBN 978-94-017-8908-0
  • About this book
Industry Sectors
Biotechnology
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Pharma