Abstract
The major permeability barrier in any membrane is the lipid bilayer structure, and its barrier property is inversely correlated with its fluidity. Bacteria cannot make this membrane much less fluid or it will start to interfere with the normal functions of the membrane proteins, so some bacteria have constructed an additional structure that surrounds the cell outside the cytoplasmic membrane. An example of this are Gram-negative bacteria, such as E. coli, which surround themselves with a second outer membrane which functions as an effective barrier.
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Selected References
Outer Membrane
Eren E, Parkin J, Adelanwa A, Cheneke B, Movileanu L, Khalid S, van den Berg B (2013) Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa, J Biol Chem 288:12042–12053
LPS and Lipid A
Bartling CM, Raetz CRH (2008) Biochemistry 47:5290–5302
Masoudi A, Raetz CRH, Zhou P, Pemble CW (2014) Nature 505:422–426
Ion Pumps
Inoue K, Ono H, Abe-Yoshizumi R, Yoshizawa S, Ito H, Kogure K, Kandori H (2013) Nat Commun 4, Article number 1678
Kaback HR (1970) Transport Ann. Rev. Biochemistry 39:561–598
Stoeckhenius W, Oesterhelt D (1975) Biophys J 15:955–962
ATP Synthase
Abrahams JP, Leslie AG, Lutter R, Walker JE (1994) Nature 370:621–628
Brandt K, Maiwald S, Herkenhoff-Hesselmann B, Gnirss K, Greie J-C, Dunn SD, Deckers-Hebestreit G (2013) J Biol Chem 288:24465–24479
Hakulinen JK, Klyszejko AL, Hoffmann J, Eckhardt-Strelau L, Brutschy B, Vonck J, Meier T (2012) Proc Natl Acad Sci 109:2050–2056
Junge W, Lill H, Engelbrecht S (1997) TIBS 22:420–423
Komoriya Y, Ariga T, Iino R, Imamura H, Okuno D, Noji H (2012) J Biol Chem 287:15134–15142
Noji H, Ryohei Y, Masasuke Y, Kinosita K Jr. (1997) Nature, 386:299–302
Preiss L, Klyszejko AL, Hicks DB, Liu J, Fackelmayer OJ, Yildiz O, Krulwich TA, Meier T (2013) Proc Natl Acad Sci USA 110:7874–7879
Toei M, Noji H (2013) J Biol Chem 288:25717–25726
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Cohen, G.N. (2014). The Outer Membrane of Gram-Negative Bacteria and the Cytoplasmic Membrane. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8908-0_2
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DOI: https://doi.org/10.1007/978-94-017-8908-0_2
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