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Mortalin Biology: Life, Stress and Death

  • Book
  • © 2012

Overview

Editors:
  1. Sunil C. Kaul

    1. National Institute of Advanced Industria, Tsukuba, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Renu Wadhwa

    1. Science & Technology (AIST), National Insitute of Advanced Industrial, Tsukuba, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • The first full-length textbook on mortalin, a member of heat shock protein family
  • Includes chapters on its abundance and functional significance in a variety of cancers
  • Comprehensive chapters on its existence and function in a wide range of fauna
  • Its role in neurological and old age disorders such as Parkinson's (PD) disease
  • The application of various mortalin reagents for bioimaging and bio-markers
  • All the authors are experts on their subject with many years of research experience
  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages 1-1
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  2. Structure and Function of Mortalin

    1. Front Matter

      Pages 1-1
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    2. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer

      • Renu Wadhwa, Sunil C. Kaul
      Pages 3-20

    3. Mortalin’s Machinery

      • Custer C. Deocaris, Sunil C. Kaul, Renu Wadhwa
      Pages 21-30

    4. The Role of Mortalin in Iron Homeostasis

      • Wen-I Luo, James A. Cowan
      Pages 31-54

    5. Functional Characteristics of Mortalin

      • Walter A. Baseler, Tara L. Croston, John M. Hollander
      Pages 55-80

  4. Mortalin in Health and Disease

    1. Front Matter

      Pages 127-127
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    2. Mortalin in Cell Protection from Immune Attack

      • Moran Saar, Oren Moskovich, Zvi Fishelson
      Pages 129-137

    3. Mortalin in Neurological Diseases

      • Jinghua Jin, Jing Zhang, Travis J. Cook, Jake G. Hoekstra
      Pages 139-158

    4. Loss of Mortalin Function in Parkinson’s Disease-Supporting the Mitochondrial Pathway of Neurodegeneration

      • Lena F. Burbulla, Rejko Krüger
      Pages 159-177

    5. Hsp75/mortalin and Protection from Ischemic Brain Injury

      • Robin E. White, Yi-Bing Ouyang, Rona G. Giffard
      Pages 179-190

    6. Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders

      • Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa, Ram K. Mishra
      Pages 191-207

    7. Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis

      • Alberto J. L. Macario, Francesco Cappello, Everly Conway de Macario
      Pages 209-221

  5. Mortalin and Cancer

    1. Front Matter

      Pages 223-223
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    2. Many Faces of Mortalin and Tid1

      • Ohad Iosefson, Abdussalam Azem
      Pages 225-244

    3. Mortalin: A Positive Regulator of Centrosome Duplication and Amplification

      • Masayuki Kanai, Kenji Fukasawa
      Pages 245-255
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Keywords

About this book

The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.

Editors and Affiliations

  • National Institute of Advanced Industria, Tsukuba, Japan

    Sunil C. Kaul

  • Science & Technology (AIST), National Insitute of Advanced Industrial, Tsukuba, Japan

    Renu Wadhwa

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