Overview
Provides a comprehensive description of the 3Rs (DNA replication, recombination, and repair) network system
Highlights the relationship between molecular mechanisms and pathology
Explains the implications in higher biological functions, such as cancer, neurology, development, ageing, and other pathologies
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Table of contents (21 chapters)
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Front Matter
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DNA Recombination
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Front Matter
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Genome Instability and Mutagenesis
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Front Matter
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Chromosome Dynamics and Functions
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Front Matter
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Keywords
About this book
This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Editors and Affiliations
Bibliographic Information
Book Title: DNA Replication, Recombination, and Repair
Book Subtitle: Molecular Mechanisms and Pathology
Editors: Fumio Hanaoka, Kaoru Sugasawa
DOI: https://doi.org/10.1007/978-4-431-55873-6
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Japan KK 2016
Hardcover ISBN: 978-4-431-55871-2Published: 29 January 2016
Softcover ISBN: 978-4-431-56717-2Published: 31 March 2018
eBook ISBN: 978-4-431-55873-6Published: 22 January 2016
Edition Number: 1
Number of Pages: IX, 555
Number of Illustrations: 18 b/w illustrations, 61 illustrations in colour
Topics: Cell Biology, Biochemistry, general, Pathology, Cytogenetics
Industry Sectors: Biotechnology, Pharma