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DNA Replication, Recombination, and Repair pp 305–339Cite as

Mismatch Repair

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Abstract

The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the removal of brominated nucleotides from DNA as well as gene conversion during genetic recombination. In the intervening 40 years, the field has developed incrementally, punctuated by a number of transformative genetic and biochemical studies. Two core MMR genes, MutS and MutL, have been conserved throughout life on earth. Defects in human MutS homologues (MSH) and MutL homologues (MLH/PMS) cause the common cancer predisposition Lynch syndrom or hereditary nonpolyposis colorectal cancer (LS/HNPCC). Work on the mechanism of MMR has been significantly aided by completely defined biochemical systems in vitro as well as several crystal snapshots that depict critical intermediates. It has been mired by unseemly biochemical conditions and misinterpretation. The contemporary use of real-time single molecule imaging has the potential to finally and fully resolve the mechanics of MMR. This review describes genetic, biochemical, and biophysical studies that contributed to the development of models for MMR.

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Authors and Affiliations

  1. Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH, 43210, USA

    Richard Fishel

  2. Department of Physics, The Ohio State University, Columbus, OH, 43210, USA

    Richard Fishel

  3. Department of Physics, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790-784, South Korea

    Jong-Bong Lee

  4. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790-784, South Korea

    Jong-Bong Lee

Authors
  1. Richard Fishel
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  2. Jong-Bong Lee
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Correspondence to Richard Fishel .

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Editors and Affiliations

  1. Dept of Life Sci, Faculty of Sci., Gakushuin University, Toshima, Tokyo, Japan

    Fumio Hanaoka

  2. Biosignal Research Center, Kobe University, Kobe, Japan

    Kaoru Sugasawa

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Fishel, R., Lee, JB. (2016). Mismatch Repair. In: Hanaoka, F., Sugasawa, K. (eds) DNA Replication, Recombination, and Repair. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55873-6_12

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