Overview
Covers the 50-year research history of P450 from its discovery to the most up-to-date progress
Provides a comprehensive overview of P450 research across many fields, including molecular biology, biotechnology, pharmacology and medicine
Includes figures and tables that facilitate understanding for young scientists interested in P450 research
Includes supplementary material: sn.pub/extras
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Table of contents (21 chapters)
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Front Matter
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Structure, Function, and Practical Applications of P450
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Front Matter
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Gene Regulation of P450
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Front Matter
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Keywords
About this book
This book encompasses major progress and future directions in cytochrome P450 (P450) research. Included are contributions by pioneers in the discovery of P450, with chapters on the molecular and functional properties of P450 and cutting-edge applications knowledge from various fields. P450 research has its roots in metabolism, but the true beginning was in 1962 with the publication by Tsuneo Omura and Ryo Sato in The Journal of Biological Chemistry on their discovery of the cytochrome. Following this groundbreaking study, over the last half-century, research has revealed that many forms of P450 exist in animals, plants and microorganisms. P450 research has expanded into many different fields including medicine, agriculture and biotechnology and has drawn the attention of industries for its bioengineering applications, such as drug development and creation of the “blue rose”. Also, research on nuclear receptors, which has grown out of research on the regulatory mechanisms of P450 genes, has become an important area in biology, medical science, pharmacology and clinical medicine—for example, with recent developments in personalized medicines. This book will draw readers into the important and exciting world of P450 and will encourage young students and scientists in P450 research to continue expanding the field via new approaches.
Editors and Affiliations
Bibliographic Information
Book Title: Fifty Years of Cytochrome P450 Research
Editors: Hiroshi Yamazaki
DOI: https://doi.org/10.1007/978-4-431-54992-5
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Japan 2014
Hardcover ISBN: 978-4-431-54991-8Published: 25 July 2014
Softcover ISBN: 978-4-431-56176-7Published: 23 August 2016
eBook ISBN: 978-4-431-54992-5Published: 23 June 2014
Edition Number: 1
Number of Pages: IX, 409
Number of Illustrations: 50 b/w illustrations, 51 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Gene Function, Pharmacology/Toxicology, Human Genetics
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Pharma