National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, USA
The condensed tannins (syn. polymeric proanthocyanidins) represent a major group of phenolic compounds in woody and some herbaceous plants (1-3). Their exceptional concentrations in the barks and heartwoods of a variety of tree species have resulted in their commercial extraction with the initial objective of applying the extracts in leather manufacture (4). Essentially all of their biological significance, e. g. the protection of plants from insects, diseases and herbivores, and most of the current, e. g. leather manufacture, and also most promising new uses, e. g. pharmaceuticals or wood preservatives, rest on their com plexation with other biopolymers like proteins and carbohydrates, or metal ions (5, 6). Increasing attention has thus been directed to understanding their conformation and conformational flexibility (7-20) in order to explain their biological activity and to provide a basis for further development of uses for these renewable phenolic compounds. Recent developments have also been initiated by the growing realization that the condensed tannins may additionally be credited for the profound health-beneficial properties of tea, fruit juices and red wine. This is mainly due to their in vitro radical scavenging (21) or antioxidant (22) biological properties, while the polymeric proanthocyanidins in red wine have been implicated in protection against cardiovascular disorders (23), e. g. the "French paradox" (24-26). Collectively these 'positive' characteristics of the polymeric proanthocyanidins have transformed "a relatively unattractive and therefore neglected area of study" (27) into, yet again, a fashionable research field.
Authors and Affiliations
Department of Chemistry, University of Alberta, Edmonton, Canada
W. A. Ayer,
L. S. Trifonov
Department of Chemistry, University of the Orange Free State, Bloemfontein, South Africa
E. V. Brandt,
J. Coetzee,
E. Malan
Department of Chemistry, Polish Academy of Sciences, Warsaw, Poland
W. M. Daniewski
National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, USA
D. Ferreira
Department of Chemistry, University of Pavia, Pavia, Italy
G. Vidari
Bibliographic Information
Book Title: Fortschritte der Chemie organischer Naturstoffe
Book Subtitle: Progress in the Chemistry of Organic Natural Products
Authors: W. A. Ayer, E. V. Brandt, J. Coetzee, W. M. Daniewski, D. Ferreira, E. Malan, L. S. Trifonov, … G. Vidari
