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Mononitrate II

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. D. G. Julian

    1. British Heart Foundation, London, UK

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  2. R. Rittinghausen

    1. Clinical Research Boehringer Mannheim GmbH, Mannheim 31, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. H. J. Überbacher

    1. Cardiovascular Clinical Research Boehringer Mannheim GmbH, Mannheim 31, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: International Boehringer Mannheim Symposia (BOEHRINGER)

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Table of contents (37 papers)

  1. Front Matter

    Pages I-XIII
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  2. Introduction

    1. Introduction

      • D. Julian
      Pages 1-2

  3. Pharmacology and Pharmacokinetics

    1. Front Matter

      Pages 3-3
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    2. Pharmacodynamics of Organic Nitrates — In Vitro and In Vivo Studies

      • K. Strein, F. Bossert, W. Bartsch, R. Hooper
      Pages 5-12

    3. Differential Effects of Isosorbide-5-Mononitrate on Epicardial Coronary Arteries and Relevant Hemodynamic Parameters: Special Aspects of Nitrate Action

      • E. Bassenge, D. J. Stewart
      Pages 13-19

    4. Effect of Isosorbide-5-Mononitrate on CoronaryCollateral Blood Flow in Dogs

      • G. J. Gross, B. Müller-Beckmann
      Pages 20-27

    5. Overview of the Pharmacokinetics of Isosorbide-5-Mononitrate

      • U. Abshagen
      Pages 28-36

    6. Slow Release Isosorbide-5-mononitrate: Advantage or Disadvantage?

      • N. Rietbrock, B. G. Woodcock, G. Menke
      Pages 37-46

    7. Pharmacokinetics of Organic Nitrates and Their Metabolites: Are They Relevant in Therapy?

      • H.-L. Fung
      Pages 47-52

  4. Effectiveness, Dose-Response Relationship and Tolerance in Patients with Angina

    1. Front Matter

      Pages 53-53
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    2. Is a Twice Daily Dosage of Isosorbide-5-Mononitrate Sufficient in the Treatment of Stable Angina Pectoris?

      • O. J. Luurila, R. Kala, P. Hirvonen, A. Kohvakka, S. Sundberg, K. Lukkala
      Pages 55-60

    3. Acute Dose Response of Isosorbide-5-Mononitrate in Patients with Effort Angina

      • J. P. Jones, Isosorbide-5-mononitrate Study Cooperative
      Pages 61-68

    4. A Comparison of Isosorbide-5-Mononitrate and Transdermal Glyceryl Trinitrate: Acute Effects and Tolerance Development During Chronic Therapy

      • W. Sehnert
      Pages 69-81

    5. Factors Influencing Tolerance in Nitrate Therapy: A Review

      • Udho Thadani
      Pages 82-98

  5. Ventricular Function and Hemodynamics

    1. Front Matter

      Pages 99-99
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    2. Nifedipine and Nitroglycerin: A Comparison of Acute Effects on Hemodynamic Determinants of Myocardial Oxygen Consumption and Supply During Exertional Angina

      • D. T. Kelly, S. Ben Freedman, G. S. Roubin, W. F. Shen, G. J. Bautovich, Ph. J. Harris et al.
      Pages 101-108

    3. Concentration-Dependent Relaxation of Isolated Human Venous Vessel Strips by Isosorbide Dinitrate and Isosorbide-5-Mononitrate

      • W. Schneider, G. Kober, M. Kraus, B. Zeidler, J. Hawlicek, D. von Loh et al.
      Pages 109-119

    4. Isosorbide-5-Mononitrate in Portal Hypertension and Cirrhosis: A Study of the Effect and Mechanism of Action

      • P. C. Hayes, D. Westaby, A. E. S. Gimson, R. Williams
      Pages 120-123

    5. Effects of Isosorbide-5-Mononitrate on Atrial-Pacing-Induced Left-Ventricular Wall Motion Abnormalities

      • S. Iliceto, A. Papa, A. Ricci, V. Lopriore, G. D’Ambrosio, P. Rizzon
      Pages 124-128

    6. Effects of Isosorbide-5-Mononitrate on Hemodynamic Parameters and Left-Ventricular Function in Patients with Coronary Heart Disease

      • P. Rubartelli, F. Abbadessa, L. Badano, F. Della Rovere, S. Mazzantini, F. Miccoli et al.
      Pages 129-132
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Keywords

About this book

A group of internationally renowned experts in the field of cardiology and pharmacology discuss the latest state-of-art in nitrate therapy. Particular emphasis is put on isosorbide-5-mononitrate (IS-5-MN). The pharmacology, pharmacokinetics, and pharmacodynamics of such therapy are described as well as its methods of action, including such aspects as denitration, increase in cyclic guanosine-monophosphate, and the endothelium derived relaxant factor. The clinical part of the book deals with dosage, effectiveness, and the development of tolerance. The effect on ventricular hemodynamics and vasospastic angina is considered. Comparative studies of IS-5-MN with other nitrates, calcium antagonists, and beta blockers using exercise testing, Holter ECG recording, and invasive techniques provide a comprehensive survey of IS-5-MN treatment of coronary heart diseases. Also summarized is the state-of-the-art regarding silent myocardial ischemia, its treatment, and models of pain perception. Mononitrate II is the follow-up volume to the previous book on mononitrates in the series International Boehringer Mannheim Symposia.

Editors and Affiliations

  • British Heart Foundation, London, UK

    D. G. Julian

  • Clinical Research Boehringer Mannheim GmbH, Mannheim 31, Federal Republic of Germany

    R. Rittinghausen

  • Cardiovascular Clinical Research Boehringer Mannheim GmbH, Mannheim 31, Federal Republic of Germany

    H. J. Überbacher

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