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Factors Influencing Tolerance in Nitrate Therapy: A Review

  • Conference paper
Mononitrate II

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

Abstract

First doses of organic nitrates in various forms produce significant hemodynamic, antianginal, and antiischemic effects [1, 2]. However, during long term therapy, tolerance to headaches, circulatory, antianginal, and antiischemic effects develops rapidly [1, 2]. The term tolerance refers to the attenuation of drug effect or complete lack of efficacy during repeated or prolonged exposure.

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Authors
  1. Udho Thadani
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Editors and Affiliations

  1. British Heart Foundation, 102 Gloucester Place, London, W1H 4DH, UK

    D. G. Julian Prof. M.D. (Medical Director) (Medical Director)

  2. Clinical Research Boehringer Mannheim GmbH, Sandhofer Straße 116, 6800, Mannheim 31, Federal Republic of Germany

    R. Rittinghausen M.D. (Director) (Director)

  3. Cardiovascular Clinical Research Boehringer Mannheim GmbH, Sandhofer Straße 116, 6800, Mannheim 31, Federal Republic of Germany

    H. J. Überbacher M.D.

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© 1987 Springer-Verlag Berlin Heidelberg

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Thadani, U. (1987). Factors Influencing Tolerance in Nitrate Therapy: A Review. In: Julian, D.G., Rittinghausen, R., Überbacher, H.J. (eds) Mononitrate II. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72689-7_11

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  • DOI: https://doi.org/10.1007/978-3-642-72689-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17832-3

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