Differential Effects of Isosorbide-5-Mononitrate on Epicardial Coronary Arteries and Relevant Hemodynamic Parameters: Special Aspects of Nitrate Action
Isosorbide-5-mononitrate (IS-5-MN) and other nitrates are potent antianginal agents. It is becoming clear that they owe their therapeutic efficacy to a very special pattern of vascular and hemodynamic response, possibly unique to this class of vasodilators. In the present review, the vasodilator spectrum of IS-5-MN will be highlighted, with special attention to the relevance of these effects for the treatment of angina pectoris. In addition, evidence will be discussed pointing to novel mechanisms, which may contribute to the unequaled performance of these agents in the treatment of ischemic heart disease.
KeywordsVentricular Filling Pressure Nitrate Action Coronary Arteriole Small Coronary Artery Coronary Artery Diameter
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