Chemical Biology of Nucleic Acids

Fundamentals and Clinical Applications

  • Volker A. Erdmann
  • Wojciech T. Markiewicz
  • Jan Barciszewski

Part of the RNA Technologies book series (RNATECHN)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Harri Lönnberg
    Pages 41-56
  3. Pascal A. Küpfer, Christian J. Leumann
    Pages 75-94
  4. Philip Nevin, Penny J. Beuning
    Pages 95-111
  5. Sarah C. Zimmermann, Katherine L. Seley-Radtke
    Pages 149-165
  6. Qing Li, Oleksandr Plashkevych, Ram Shankar Upadhayaya, Sachin Gangadhar Deshpande, Andras Földesi, Jyoti Chattopadhyaya
    Pages 199-226
  7. Ramon Eritja, Montserrat Terrazas, Santiago Grijalvo, Anna Aviñó, Adele Alagia, Sónia Pérez-Rentero et al.
    Pages 227-242
  8. Eileen Magbanua, Ulrich Hahn
    Pages 271-292
  9. Diana Bauermeister, Maike Claußen, Tomas Pieler
    Pages 293-308
  10. Wendy W. K. Mok, Simon A. McManus, Yingfu Li
    Pages 309-323
  11. Anders Hauge Okholm, David Schaffert, Jørgen Kjems
    Pages 325-345

About this book


This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.


From bench to bed Molecular basis of disease Molecular medicine Non coding RNA RNA silencing Therapeutic nucleic acids

Editors and affiliations

  • Volker A. Erdmann
    • 1
  • Wojciech T. Markiewicz
    • 2
  • Jan Barciszewski
    • 3
  1. 1.Institute of Chemistry/BiochemistryFree University BerlinBerlinGermany
  2. 2.Institute of Bioorganic ChemistryPolish Academy of SciencesPoznanPoland
  3. 3.Institute of Bioorganic ChemistryPolish Academy of SciencesPoznanPoland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-54451-4
  • Online ISBN 978-3-642-54452-1
  • About this book
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