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Asthma: Targeted Biological Therapies

  • Girolamo Pelaia
  • Alessandro Vatrella
  • Rosario Maselli

Table of contents

  1. Front Matter
    Pages i-vi
  2. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 1-4
  3. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 5-15
  4. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 17-25
  5. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 27-49
  6. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 51-66
  7. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 67-81
  8. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 83-87
  9. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 89-91
  10. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 93-96
  11. Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
    Pages 97-99

About this book

Introduction

This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.

Keywords

IL-13 IL-4 IL-5 airway remodelling in asthma anti-IgE anti-TNFalpha antibodies cellular and molecular mechanisms of asthma eosinophils innate cytokines

Authors and affiliations

  • Girolamo Pelaia
    • 1
  • Alessandro Vatrella
    • 2
  • Rosario Maselli
    • 3
  1. 1.University “Magna Graecia”CatanzaroItaly
  2. 2.University of SalernoSalernoItaly
  3. 3.University “Magna Graecia”CatanzaroItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-46007-9
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-46005-5
  • Online ISBN 978-3-319-46007-9
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology