Nanoscale Insights into Ion-Beam Cancer Therapy

  • Andrey V. Solov’yov

Table of contents

  1. Front Matter
    Pages i-xx
  2. Eugene Surdutovich, Andrey V. Solov’yov
    Pages 1-60
  3. Alexey Verkhovtsev, Pedro Arce, Antonio Muñoz, Francisco Blanco, Gustavo García
    Pages 99-119
  4. Patrick Rousseau, Bernd A. Huber
    Pages 121-157
  5. Ilko Bald, Roman Čurík, Janina Kopyra, Michal Tarana
    Pages 159-207
  6. Paola Bolognesi, Lorenzo Avaldi
    Pages 209-235
  7. Alexey Verkhovtsev, Andrei V. Korol, Andrey V. Solov’yov
    Pages 237-276
  8. P. M. Dinh, L. Bouëssel du Bourg, C.-Z. Gao, Bin Gu, L. Lacombe, M. McAllister et al.
    Pages 277-309
  9. Pablo de Vera, Nigel J. Mason, Eugene Surdutovich, Andrey V. Solov’yov
    Pages 339-357
  10. Alexey Verkhovtsev, Eugene Surdutovich, Andrey V. Solov’yov
    Pages 359-377
  11. M. Bolsa Ferruz, V. Ivošev, K. Haume, L. Ellis-Gibbings, A. Traore, V. Thakare et al.
    Pages 379-434
  12. Ludovic De Marzi, Annalisa Patriarca, Alejandro Mazal, Jean-Louis Habrand
    Pages 467-494
  13. Back Matter
    Pages 495-498

About this book

Introduction

This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

Keywords

COST Action Nano-IBCT Collisions and DNA double strand breaks Dissociative electron attachment process Heavy ion therapy Ion-beam cancer therapy Irradiation of biological targets with ions Multiscale approach to ion-beam cancer therapy Proton-beam cancer therapy Radiation damage in biological systems Radiation dosimetry Radiation nanochemistry Radiobiological effects with nanoparticles

Editors and affiliations

  • Andrey V. Solov’yov
    • 1
  1. 1.Frankfurter Innovationszentrum BiotechnologieMBN Research Center FrankfurtGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-43030-0
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-319-43028-7
  • Online ISBN 978-3-319-43030-0
  • About this book
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