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Ion Collisions with Biomolecules and Biomolecular Clusters

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Nanoscale Insights into Ion-Beam Cancer Therapy

Abstract

In this chapter we describe the recent progress which has been made in experimental studies of ion collisions with biomolecular systems, either in form of isolated biomolecules in the gas phase or as clusters containing up to several tens of biomolecules. Most of the work has been performed with projectiles which play an important role in ion beam cancer therapy applications as protons or multiply charged ions of carbon and oxygen. The biomolecular targets are characterized by an increasing complexity and include water molecules, nucleobases, nucleosides and nucleotides, as well as amino acids and protein segments. Other complex targets are heterogeneous clusters containing biomolecular systems which are embedded in a water environment. After an introduction to ion-molecule collisions using \(\text {C}_{60}\) fullerene as a model system, we will review ionization and charge transfer processes as well as ion-induced fragmentation studies. Finally we will discuss the effect of the environment considering clusters of biomolecules including hydrated systems.

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Authors and Affiliations

  1. Normandie Univ, ENSICAEN, UNICAEN, CEA, CNRS, CIMAP, 14000, Caen, France

    Patrick Rousseau

  2. Centre de Recherche sur les Ions, les Matériaux et la Photonique (CIMAP), Unité Mixte CEA-CNRS-EnsiCaen-Université de Caen Basse-Normandie, UMR 6252, 6 Boulevard Maréchal Juin, 14050, Caen, France

    Bernd A. Huber

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  1. Frankfurter Innovationszentrum Biotechnologie, MBN Research Center , Frankfurt, Germany

    Andrey V. Solov’yov

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Rousseau, P., Huber, B.A. (2017). Ion Collisions with Biomolecules and Biomolecular Clusters. In: Solov’yov, A. (eds) Nanoscale Insights into Ion-Beam Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-43030-0_4

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