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Psychoactive Drugs

Tolerance and Sensitization

  • Book
  • © 1989

Overview

Editors:
  1. Andrew J. Goudie

    1. Department of Psychology, University of Liverpool, Liverpool, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael W. Emmett-Oglesby

    1. Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Neuroscience (CNEURO)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xv
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  2. Tolerance and Sensitization: Overview

    1. Tolerance and Sensitization: Overview

      • Andrew J. Goudie, Michael W. Emmett-Oglesby
      Pages 1-13

  3. Behavioral Mechanisms

    1. Front Matter

      Pages 15-15
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    2. The Role of Instrumental Learning in Behavioral Tolerance to Drugs

      • David L. Wolgin
      Pages 17-114

    3. Pharmacological Conditioning and Drug Effects

      • Shepard Siegel
      Pages 115-180

    4. Behavioral and Pharmacological History as Determinants of Tolerance- and Sensitization-Like Phenomena in Drug Action

      • James E. Barrett, John R. Glowa, Michael A. Nader
      Pages 181-219

    5. Tolerance to Drug Discriminative Stimuli

      • Alice M. Young, Christine A. Sannerud
      Pages 221-278

  4. Molecular Mechanisms

    1. Front Matter

      Pages 279-279
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    2. Dispositional Mechanisms in Drug Tolerance and Sensitization

      • A. D. Lê, Jatinder M. Khanna
      Pages 281-351

    3. Dopamine Receptor Changes During Chronic Drug Administration

      • Andrew J. Greenshaw, Glen B. Baker, Thomas B. Wishart
      Pages 353-406

    4. Sensitization to the Actions of Antidepressant Drugs

      • Paul Willner
      Pages 407-459

    5. Adaptation in Neuronal Calcium Channels as a Common Basis for Physical Dependence on Central Depressant Drugs

      • John M. Littleton, Hilary J. Little
      Pages 461-518

  5. Summary Chapters

    1. Front Matter

      Pages 519-519
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    2. Behavioral Tolerance and Sensitization

      • Derek E. Blackman
      Pages 521-545

    3. Drug Tolerance and Sensitization

      • Harold Kalant
      Pages 547-577

  6. Back Matter

    Pages 579-600
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Keywords

About this book

Research into the processes of tolerance and sensitization has escalated at a substantial rate in recent years, presumably because of the fundamental importance of understanding the long-term, as opposed simply to the initial, acute effects of drugs. The rapid of such research in recent years is documented c1early by growth the editors in the introductory chapter to this text. However, despite the fact that there is a very large amount of literature concemed with the effects of long-term drug treatment, there is, to the best of our knowledge, no published text that has ever attempted to integrate some of the many diverse findings that have been made in this area. Basic research has uncovered a num­ ber of different mechanisms by which tolerance and sensitization to drugs can develop. Such mechanisms are of very different types, involving psychological behavioral, metabolic, neuronal, and subcellular processes. Because of the complexity of each of these different types of mechanisms, with few exceptions, individual re­ searchers usually tend, understandably, to concentrate on their own specific areas of expertise, paying relatively little attention to rele­ vant research occurring in other areas. Consequently, they neglect or simply ignore the important question of the relative importance of the specific mechanism that they are studying, and the related question of the possible interrelationships that may exist between different mechanisms for the production of tolerance and sensitiza­ tion.

Editors and Affiliations

  • Department of Psychology, University of Liverpool, Liverpool, UK

    Andrew J. Goudie

  • Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, USA

    Michael W. Emmett-Oglesby

Bibliographic Information

  • Book Title: Psychoactive Drugs

  • Book Subtitle: Tolerance and Sensitization

  • Editors: Andrew J. Goudie, Michael W. Emmett-Oglesby

  • Series Title: Contemporary Neuroscience

  • DOI: https://doi.org/10.1007/978-1-59259-464-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Hardcover ISBN: 978-0-89603-148-7Published: 01 September 1989

  • Softcover ISBN: 978-1-4757-6323-2Published: 15 January 2013

  • eBook ISBN: 978-1-59259-464-1Published: 01 September 1989

  • Edition Number: 1

  • Number of Pages: XV, 600

  • Topics: Neurosciences

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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