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Adaptation in Neuronal Calcium Channels as a Common Basis for Physical Dependence on Central Depressant Drugs

  • Chapter
Psychoactive Drugs

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

There are many ways of approaching the study of drug tolerance and dependence, as exemplified in the various chapters in this book. What we have attempted in this chapter is to take one of the simplest properties of neurones, that is, their electrical excitability, to consider how this might be modified by central depressant drugs and how neurones might therefore adapt to the presence of such drugs. We have then reviewed the neurochemical and behavioral evidence that supports the concept that such adaptation might lead to tolerance and physical dependence. We have, therefore, deliberately oversimplified the situation in an attempt to provide a framework on which more complex explanations can be built. We believe this is justified, not least because it has led to the wide-ranging and testable hypothesis embodied in the title.

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  1. John M. Littleton
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  2. Hilary J. Little
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  1. Department of Psychology, University of Liverpool, Liverpool, UK

    Andrew J. Goudie

  2. Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, Texas, USA

    Michael W. Emmett-Oglesby

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Littleton, J.M., Little, H.J. (1989). Adaptation in Neuronal Calcium Channels as a Common Basis for Physical Dependence on Central Depressant Drugs. In: Goudie, A.J., Emmett-Oglesby, M.W. (eds) Psychoactive Drugs. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-464-1_9

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  • DOI: https://doi.org/10.1007/978-1-59259-464-1_9

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