Overview
- Editors:
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Eyal Raz
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University of California, San Diego, La Jolla, USA
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About this book
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Table of contents (31 chapters)
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Vaccination Strategies
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- Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi et al.
Pages 203-218
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- Christina C. N. Wu, Chih Min Tang, Brian Crain, Maripat Corr
Pages 219-226
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Applications—Infectious Diseases
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Front Matter
Pages 227-227
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- Michael J. McCluskie, Risini D. Weeratna, Heather L. Davis
Pages 229-238
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- Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, Eyal Raz
Pages 239-254
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- Dennis M. Klinman, Ken J. Ishii, Ihsan Gursel
Pages 255-263
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- Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, Antonino Catanzaro
Pages 265-275
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Applications—Allergy
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Front Matter
Pages 277-277
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- Anthony A. Horner, Eyal Raz
Pages 279-287
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- Reid K. Ikeda, Kenji Takabayashi, David Broide
Pages 289-299
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- Kunihiko Kitagaki, Joel N. Kline
Pages 301-314
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- Andrea Keane-Myers, Chi-Chao Chan
Pages 315-325
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Applications—Cancer
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Front Matter
Pages 327-327
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- Thomas L. Warren, George J. Weiner
Pages 329-337
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Inflammation and Autoimmunity
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Front Matter
Pages 339-339
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- Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, Lena Mölne
Pages 351-361
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- Sarah T. A. Roord, Arash Ronaghy, Berent J. Prakken, Kenji Takabayashi, Dennis A. Carson
Pages 363-371
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- Daniel Rachmilewitz, Fanny Karmeli, Leonor Leider-Trejo, Kenji Takabayashi, Tomoko Hayashi, Eyal Raz
Pages 373-381
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Safety Considerations
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Front Matter
Pages 383-383
Reviews
"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News
"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal
Editors and Affiliations
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University of California, San Diego, La Jolla, USA
Eyal Raz