Abstract
Joint destruction in rheumatoid arthritis is caused by an invasive pannus, composed of activated macrophages and fibroblasts. The disease is thought to have an immunological origin because of
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1.
The abundant immune complexes, complement split products, and rheumatoid factor autoantibodies in affected joints,
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2.
The close association of the disease with HLA DRβ1 types that express the QKRAA shared epitope,
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3.
The accumulation within the joints of activated lymphocytes and monocytes.
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Roord, S.T.A., Ronaghy, A., Prakken, B.J., Takabayashi, K., Carson, D.A. (2002). The Role of Immunostimulatory DNA Sequences in Arthritis. In: Raz, E. (eds) Microbial DNA and Host Immunity. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-305-7_29
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DOI: https://doi.org/10.1007/978-1-59259-305-7_29
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