Overview
- Assists academic and industrial researchers involved in drug and probe discovery to adopt label-free techniques
- Provides fundamental and practical methods from expert researchers
- Includes tips and key implementation advice to aid in translating techniques to your own lab
Part of the book series: Methods in Pharmacology and Toxicology (MIPT)
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Table of contents (21 protocols)
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Front Matter
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Review
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Front Matter
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Biochemical Profiling and Screening
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Front Matter
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Cell Phenotypic Profiling and Screening
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Front Matter
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Keywords
About this book
This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab.
Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.
Editors and Affiliations
Bibliographic Information
Book Title: Label-Free Biosensor Methods in Drug Discovery
Editors: Ye Fang
Series Title: Methods in Pharmacology and Toxicology
DOI: https://doi.org/10.1007/978-1-4939-2617-6
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2015
Hardcover ISBN: 978-1-4939-2616-9Published: 07 April 2015
Softcover ISBN: 978-1-4939-4961-8Published: 05 October 2016
eBook ISBN: 978-1-4939-2617-6Published: 06 April 2015
Series ISSN: 1557-2153
Series E-ISSN: 1940-6053
Edition Number: 1
Number of Pages: XI, 390
Number of Illustrations: 21 b/w illustrations, 93 illustrations in colour
Topics: Pharmacology/Toxicology
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Health & Hospitals, Pharma