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Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysis

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Label-Free Biosensor Methods in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Cell-based biosensors are one kind of devices that employ immobilized living cells as sensing elements combined with sensors or transducers to detect the intracellular and extracellular microenvironment conditions, physiological parameters and responses of cells upon stimulation. Because of their advantages associated with long-term recording in a noninvasive way, fast response time, and label-free experimentation, these biosensors have been widely utilized in many fields such as cellular physiological analysis, pharmaceutical evaluation, environmental monitoring, and medical diagnosis. Drug toxicology analysis is a vital step in drug discovery and development. This chapter discusses the principles and applications of cell-based biosensors including microelectrode arrays, electrical cell–substrate impedance sensing, field effect transistors, light-addressable potentiometric sensors, patch-clamp chips, quartz crystal microbalance in drug toxicology analysis.

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Authors and Affiliations

  1. Biosensor National Special Laboratory, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, P. R. China

    Jie Zhou, Xianxin Qiu & Ping Wang

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  1. Jie Zhou
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  2. Xianxin Qiu
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  3. Ping Wang
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Correspondence to Ping Wang .

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  1. Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York, USA

    Ye Fang

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Zhou, J., Qiu, X., Wang, P. (2015). Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysis. In: Fang, Y. (eds) Label-Free Biosensor Methods in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2617-6_4

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  • DOI: https://doi.org/10.1007/978-1-4939-2617-6_4

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