Advertisement

Drugs Affecting Leukotrienes and Other Eicosanoid Pathways

  • B. Samuelsson
  • F. Berti
  • G. C. Folco
  • G. P. Velo
Book

Part of the NATO ASI Series book series (NSSA, volume 95)

Table of contents

  1. Front Matter
    Pages i-x
    PDF
  2. Introduction
    Bengt Samuelsson
    Pages 1-3
  3. Measurement of Thromboxane Production in Vivo: Metabolic and Analytical Aspects
    E. Granström, P. Westlund, M. Kumlin, A. Nordenström
    Pages 5-17
  4. High Pressure Liquid Chromatography-125J-RIA, A Sensitive and Specific Prostaglandin Assay
    T. Mourits-Andersen, R. Jensen, J. Dyerberg
    Pages 19-30
  5. Enzyme Immunoassays of Icosanoids Using Acetylcholinesterase
    P. Pradelles, J. Maclouf, J. Grassi
    Pages 31-38
  6. Syntheses and Biological Effects of Leukotrienes and Analogs
    Bernd Spur, Attilio Crea, Wilfried Peters
    Pages 39-53
  7. Pharmacologic Modulation of Leukotriene Biosynthesis by Incorporation of Alternative Unsaturated Fatty Acids (20:5 and 22:6)
    Robert A. Lewis, Tak H. Lee, K. Frank Austen
    Pages 55-71
  8. Studies with Inhibitors of Leukotriene Biosynthesis with Special Reference to Piriprost (U-60,257)
    Michael K. Bach
    Pages 73-86
  9. Pulmonary and Vascular Effects of Leukotrienes: Involement in Asthma and Inflation
    Per Hedqvist, Sven-Erik Dahlén
    Pages 87-101
  10. Modulation of the Release of Leukotrienes and Prostaglandins and of their Functional Effects in Human and Guinea-Pig Lung Parenchyma
    G. C. Folco, L. Sautebin, G. Rossoni, T. Viganò, M. T. Crivellari, G. Galli et al.
    Pages 103-120
  11. Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species
    Marwa N. Samhoun, Priscilla J. Piper, Neil C. Barnes
    Pages 121-129
  12. The Effects of Low-Dose Aspirin and Selective Inhibitors of Thromboxane-Synthase on Eicosanoid Production in Man
    Carlo Patrono, Paola Filabozzi, Paola Patrignani
    Pages 131-140
  13. Manipulation of Pro- and Antiaggregating Prostaglandins: New Antithrombotic Strategies
    H. Deckmyn, P. Gresele, J. Arnout, J. Vermylen
    Pages 141-147
  14. Flavonoids — Lipoxygenases — Platelet Aggregation
    R. J. Gryglewski, J. Robak, J. Swięs
    Pages 149-166
  15. Transformation of 15-Hydroperoxyeicosapentaenoic Acid Into Mono-and Dihydroxyeicosapentaenoic Acids by Human Platelets
    Bing Lam, Ewa Marcinkiewicz, Patrick Y-K Wong
    Pages 167-180
  16. Metabolism of Arachidonic Acid by 12- and 15-Lipoxygenases in Human Platelets and Polymorphonuclear Leukocytes
    Patrick Y-K Wong, Par Westlund, Mats Hamberg, Elisabeth Granstrom, Patricia H-W Chao, Bengt Samuelsson
    Pages 181-195
  17. Epoxidation of Arachidonic Acid and Prostacyclin in the Kidney
    Patrick Y-K. Wong, John C. McGiff, Michal Schwartzman, F. F. Sun
    Pages 197-210
  18. The Effect of 9α-Fluorohydrocortisone on the Urinary Excretion of 6-KETO-PGF1α in Man
    P. Minuz, G. Capuzzo, M. Degan, C. Lechi, G. Covi, G. P. Velo et al.
    Pages 211-220
  19. Prostacyclin in Therapy of Vascular Disease
    R. J. Gryglewski, A. Szczeklik
    Pages 221-238
  20. LTC4 Induces Hyperreactivity of the Isolated Vascular Tissue to Histamine, Serotonin and Norepinephrine
    L. Daffonchio, C. Omini, G. Brunelli, F. Berti
    Pages 239-247
  21. Evidence for a Thromboxane Antagonist in Selected InVitro and InVivo Systems
    P. E. Malo, M. A. Wasserman, R. R. Osborn
    Pages 249-263
  22. Precursor-Product Relationship in Vascular Eicosanoid Formation after Manipulation of Dietary Fatty Acids in Experimental Animals
    C. Galli, E. Giani, I. Masi
    Pages 265-275
  23. Formation of Leukotrienes and other Eicosanoids in the Gastrointestinal Tract and Effect of Drugs
    Brigitta M. Peskar, Karl W. Dreyling, Klaus Schaarschmidt, Harald Goebell
    Pages 277-294
  24. Role of Eicosanoids in the Pathogenesis of Inflammatory Bowel Diseases
    Brendan J. R. Whittle, Nigel K. Boughton-Smith, Christopher J. Hawkey
    Pages 295-310
  25. Inhibition of 5’lipoxygenase: Relevance to Inflammation
    R. M. J. Palmer, J. A. Salmon
    Pages 311-330
  26. The Role of Glucocorticoid-Induced Phospholipase Inhibitory Proteins
    Massimo Di Rosa
    Pages 331-337
  27. Formation and Oxidative Degradation of Leukotrienes by Eosinophils and Neutrophils
    William R. Henderson
    Pages 339-349
  28. Eicosanoids and Cancer
    Alan Bennett
    Pages 351-357
  29. Stimulated Human Colonic Synthesis of Arachidonate Lipoxygenase and Cyclo-Oxygenase Products by Laxatives
    F. Capasso, I. A. Tavares, A. Bennett
    Pages 359-362
  30. Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with a 23187 or Melittin
    Monique Braquet, Mara d’Onofrio, Ricardo Garay, Pierre Braquet
    Pages 363-380
  31. Back Matter
    Pages 381-394
    PDF

About this book

Keywords

Acetylcholin Glucocorticoid Histamin Prostaglandin asthma cancer cell chromatography diseases drugs inflammation kidney metabolism pharmacology serotonin

Editors and affiliations

  • B. Samuelsson
    • 1
  • F. Berti
    • 2
  • G. C. Folco
    • 2
  • G. P. Velo
    • 3
  1. 1.Karolinska InstituteStockholmSweden
  2. 2.University of MilanMilanItaly
  3. 3.University of VeronaVeronaItaly

Bibliographic information

Industry Sectors
Pharma
Chemical Manufacturing
Biotechnology
Consumer Packaged Goods